Glycaemic and Insulinaemic Responses After Consumption of FOS.

Postprandial Glycaemic and Insulinaemic Responses After Consumption of Minicakes Containing FOS in Adults

The study aims to evaluate the glycaemic and insulinaemic response of short-chain fructo-oligosaccharides (scFOS) used to replace sugars (e.g. dextrose) in foods.

Inclusion Criteria:

• Body mass index (BMI) between 18.0 and 25.0 kg/m² (included);
• Ready to keep the same volume of physical activity and the same dietary habits during the study and particularly 24 hours before each visit;
• Be used to have breakfast;
• Non-smoker for at least 3 months;
• For the female participant: not being pregnant or breastfeeding and using efficient birth control;
• Signed the consent form;
• Able to follow the instructions of the study;
• Health insured;
• Accepted to be included in the National Registry for biomedical research Volunteers (Fichier VRB, Volontaires Recherches Biomédicales).

Exclusion Criteria:

• Fasting blood glucose over 6.1 mmol/L (1.10 g/L) (or diabetes treated or not);
• Fasting blood cholesterol over 6.35 mmol/L;
• Fasting blood triglycerides over 1.70 mmol/L (or history of insulinoma);
• Fasting blood insulin under 20 mU/L;
• Fasting HbA1c under 7%;
• History of hypercholesterolemia, hypertension, diabetes or glucose intolerance treated or not;
• History of dietary allergies or coeliac disease;
• History of digestive system disease susceptible to modify digestion or absorption like Crohn's disease;
• Somatic or psychiatric disorders;
• Renal insufficiency (kidney failure);
• SGOT or ALAT over 52.5 U/L;
• Smoker;
• Consuming more than 3 alcoholic beverage a day;
• Weight varied 3 kg the last 3 months.