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The aim of the investigators study is to investigate the effects of anaesthetic preconditioning with sevoflurane during organs harvesting in brain dead donors. More particularly, the investigators will investigate whether sevoflurane preconditioning protects against ischaemia-reperfusion the livers and kidneys allografts after a prolonged period of cold ischaemia and whether this protection translates in a better clinical functional recovery of these allografts.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sevoflurane | Active Comparator | 1 MAC of sevoflurane for 15 minutes before organs procurement. |
|
| No intervention | No Intervention | No volatile anesthetics during organs procurement |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sevoflurane | Drug | In the sevoflurane group, the anesthetic agent has to be administered immediately after arrival in the operating room to reach an end-expiratory target concentration of 2%. This concentration of sevoflurane should be maintained until the procedural cardiac arrest and for at least 15 min. |
| Measure | Description | Time Frame |
|---|---|---|
| Composite outcome of liver function following liver transplantation. |
| First week post-transplantation |
| Measure | Description | Time Frame |
|---|---|---|
| • Incidence of primary non function (liver failure requiring emergent re-transplantation) | 30-day and 6-month after transplantation. | |
| • Hospital length of stay. | 30-day and 6-month after transplantation. |
| Measure | Description | Time Frame |
|---|---|---|
| Composite outcome of post transplantation kidney function. | • Creatinine on the first post-transplantation blood test and on the following samples from the first to the 7th postoperative days. Maximal creatinine values and values at 72-hour after transplantation, the time for 50% decline, and the area under the curve during the first postoperative week. | First week after transplantation, 30 day and 6-month. |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jean L Joris, MD, PhD | Contact | 32-4-3667180 | jean.joris@chu.ulg.ac.be |
| Name | Affiliation | Role |
|---|---|---|
| Jean L Joris, MD, PhD | CHU Liège - Belgium | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesiology, CHU Liège | Liège | B-4000 | Belgium |
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|
| • Allograft function (yes/no) at 30-day and 6-month after transplantation. | 30-day and 6-month after transplantation. |
| • Hospital mortality and at 30-day. | 30-day. |
| • Delayed graft function : (defined as dialysis during first postop wk; decline in creatinine value |
| First week after transplantation, 30 day and 6-month. |
| • Length of delayed graft function. | First week after transplantation, 30 day and 6-month. |
| • Primary non function (patient who must go back to chronic hemodialysis and must be listed for re-transplantation | patient who must go back to chronic hemodialysis and must be listed for re-transplantation, at 30-day and 6-month after transplantation. | First week after transplantation, 30 day and 6-month. |
| • Hospital length of stay. | First week after transplantation, 30 day and 6-month. |
| • Hospital mortality and mortality at 30-day. | First week after transplantation, 30 day and 6-month. |
| ID | Term |
|---|---|
| D000077149 | Sevoflurane |
| ID | Term |
|---|---|
| D008738 | Methyl Ethers |
| D004987 | Ethers |
| D009930 | Organic Chemicals |
| D006845 | Hydrocarbons, Fluorinated |
| D006846 | Hydrocarbons, Halogenated |
| D006838 | Hydrocarbons |
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