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Esophageal Motility in eosinophilic esophagitis will be evaluated by High Resolution Manometry before and after medical treatment - motility is suspected to change/improve after therapy.
After identification of eosinophilic inflammation of the esophagus -> differentiation between GERD and eosinophilic esophagitis (via pH/MII-measurements or PPI-trial) -> High-resolution manometry (HRM) for evaluation of esophageal motility in patients with eosinophilic esophagitis (exclusion of GERD-patients)-> initiation of budesonide-therapy -> after eight weeks of therapy reevaluation of esophageal motility by HRM
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Eosinophilic esophagitis | Other | Patients with eosinophilic esophagitis after exclusion of GERD |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High resolution manometry (HRM) | Device | High resolution manometry of the esophagus |
|
| Measure | Description | Time Frame |
|---|---|---|
| Improvement of esophageal motility (IBP) measureable in high resolution manometry (HRM) | Average maximum intra-bolus-pressure (IBP) [mmHg] before and after therapy | Two months |
| Measure | Description | Time Frame |
|---|---|---|
| Improvement of esophageal motility (e.g. specified in the chicago classification) represented in high resolution manometry (HRM) | weak peristalsis with small/large breaks, frequently failes peristalsis, absent peristalsis, hypertensive peristalsis, rapid contractions with normal latency, functional EGJ-obstruction, panesophageal pressurizations, compartimentalized pressurizations; | Two months |
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Inclusion Criteria:
• patients with eosinophilic inflammation of the esophagus
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Simon Nennstiel | Contact | +49 89 4140 5055 | simon.nennstiel@lrz.tum.de | |
| Christoph Schlag | Contact | +49 89 4140 5055 | christoph.schlag@lrz.tum.de |
| Name | Affiliation | Role |
|---|---|---|
| Simon Nennstiel, Dr. med. | Klinikum rechts der Isar, II. Med. Klinik | Principal Investigator |
| Christoph Schlag, Dr. med. | Klinikum rechts der Isar, II. Med. Klinik | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Klinikum rechts der Isar, II. Medizinische Klinik | Recruiting | München | 81675 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30614939 | Derived | Weidlich S, Nennstiel S, Jesinghaus M, Brockow K, Slotta-Huspenina J, Bajbouj M, Schmid RM, Schlag C. IgG4 is Elevated in Eosinophilic Esophagitis but Not in Gastroesophageal Reflux Disease Patients. J Clin Gastroenterol. 2020 Jan;54(1):43-49. doi: 10.1097/MCG.0000000000001154. |
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| ID | Term |
|---|---|
| D057765 | Eosinophilic Esophagitis |
| D005764 | Gastroesophageal Reflux |
| ID | Term |
|---|---|
| D004941 | Esophagitis |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
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| Endoscopic evaluation of inflammation before/after therapy | Endoscopic assessment of esophageal signs of eosinophilic esophagitis (white exsudates, furrows, edema, rings, crepe paper, stricture | Two months |
| Symptoms before/after therapy | Evaluation of symptoms via questionnaire before/after therapy | Two months |
| Monther Bajbouj, PD Dr. med. |
| Klinikum rechts der Isar, II. Med. Klinik |
| Principal Investigator |
| D005759 |
| Gastroenteritis |
| D004802 | Eosinophilia |
| D007960 | Leukocyte Disorders |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D015154 | Esophageal Motility Disorders |
| D003680 | Deglutition Disorders |