Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Principal investigator has left the Institution
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
High Resolution Manometry is a new technology that utilizes 36 solid state sensors on a thin catheter spaced at 1-cm intervals. One can more effectively measure the pressure of the esophagus. It includes a sophisticated software to display the pressures data as color topography plot using time, length of the esophagus and pressure within the entire esophagus. It is unclear if this technology improvement actually correlates with patient's symptoms.
In a 2007 retrospective study performed using this technology, 400 subjects referred to the motility lab underwent high resolution manometry (HRM) for complaints of dysphasia, gastroesophageal reflux disease, chest pain and miscellaneous complaints. HRM offered greater detail of individual contracting segments of the esophagus, including the duration of contraction and propagation of individual contractions.
For example, a new subclass of achalasia was defined by HRM. In this classification, achalasia is divided into types 1, 2 and 3. Type 1 corresponds to classic achalasia (complete esophageal motor failure), type 2 is a compression achalasia (simultaneous panesophageal pressurization with aperistalsis), and type 3 is spastic achalasia with aperistalsis (100% spasm). However, it is unclear if this categorization represents a spectrum of disease among patients with achalasia, or it represents distinct subgroups of patients with different symptom presentation and etiology.
This study will attempt to correlate the data from HRM to patient's chief compliants, symptom severity, and clinical presentation.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Type I achalasia | classic achalasia: complete esophageal motor failure |
| |
| Type II achalasia | compression achalasia: simultaneous panesophageal pressurization with aperistalsis |
| |
| Type III achalasia | spastic achalasia with aperistalsis: 100% spasm |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High Resolution Manometry | Procedure | High Resolution Manometry which uses 36 solid state sensors spaced at 1-cm intervals, positioned from the hypopharynx to the stomach. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Differences and similarities in patients with achalasia | To determine the differences and similarities in the clinical presentation of patients with type 1, 2 and 3 achalasia based on the Chicago classification for HRM | at 24 months |
| Measure | Description | Time Frame |
|---|---|---|
| Esophageal dysmotility in patients with dysphagia and GERD symptoms | To determine the prevalence of esophageal dysmotility using the Chicago classification based on primary chief complaints. | at 24 months |
| HRM parameters |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Subjects will be recruited from patients referred to the University Medical Associates motility lab for high resolution manometry
Not provided
| Name | Affiliation | Role |
|---|---|---|
| John Wo, MD | University of Louisville School of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Louisville | Louisville | Kentucky | 40202 | United States |
Not provided
| ID | Term |
|---|---|
| D004931 | Esophageal Achalasia |
| D003680 | Deglutition Disorders |
| D005764 | Gastroesophageal Reflux |
| D002637 | Chest Pain |
| ID | Term |
|---|---|
| D015154 | Esophageal Motility Disorders |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D008365 | Manometry |
| ID | Term |
|---|---|
| D008919 | Investigative Techniques |
Not provided
Not provided
Not provided
Not provided
Not provided
|
To determine if HRM parameters reflect esophageal physiology between contractile strength of the esophagus and GEJ residual pressure obstructing esophageal flow.
| at 24 months |
| Esophageal dysmotility in patients with postfundoplication compliants | To determine the prevalence of esophageal dysmotility using the Chicago classification based in patients with postfundoplication complaints. | at 24 months |
| Correlation between HRM and symptoms | To determine if HRM parameters reflect symptom presentations. | At 24 months |
| D010608 | Pharyngeal Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |