Short-term Function and Pain After Treatment for Dupuytren's Disease

Comparing Short-term Function and Pain After Treatment With Collagenase Clostridium Histolyticum or Percutaneous Needle Aponeurotomy for Dupuytren's Disease

This study will evaluate short-term pain and function associated with percutaneous needle aponeurotomy (PNA) and injections of the enzyme collagenase clostridium histolyticum in patients with Dupuytren's disease. Scores on outcome measures will be compared between groups to determine whether treatments differ in terms of hand function and pain during the early post-treatment period.

Percutaneous needle aponeurotomy (PNA) and injections of the enzyme collagenase clostridium histolyticum are two non-invasive treatment options for patients with Dupuytren's disease. While PNA has been offered for decades, injectable collagenase is relatively new. The effectiveness of each treatment has been compared in the literature; however, recovery, in terms of pain and short-term function has not been formally evaluated. The objective of this study is to objectively compare short-term function and pain outcomes associated with each of these two procedures in patients presenting with untreated Dupuytren's disease.

Inclusion Criteria:

• Adult
• Dupuytren's disease diagnosis
• Consented to either percutaneous needle aponeurotomy or Xiaflex injection (patient choice)
• Able to read/write/speak English
• Must have an email address

Exclusion Criteria:

• Previous treatment for Dupuytren's disease
• Type 2 Diabetes Mellitus
• Pre-existing hand condition, previous hand surgery or trauma