Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Individuals with Cirrhosis have been shown to have a low aerobic capacity. While supervised exercise training has been shown to be an effective intervention to remedy this, there is currently no data on home based exercise interventions in this population. This study will evaluate the effects of a home based exercise program on the aerobic capacity of enrolled early stage liver cirrhosis patients, as well as changes in quality of life, thigh muscle thickness, and thigh muscle oxygen consumption.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Home based aerobic exercise | Experimental | Home based aerobic exercise on cycle ergometer. Three times per week, 30-60 minutes per session. |
|
| Usual Care group | No Intervention | These patients will continue with their normal activities of daily living and will not be provided with equipment or coaching for home based exercise during the study period . |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Home based Aerobic exercise training | Behavioral |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in peak exercise pulmonary oxygen uptake (VO2peak). | Baseline (day 1) and Study End (8 weeks) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in muscle mass as measured by thigh ultrasound | Baseline (day 1) and Study end (8 weeks) | |
| Change in quality of life - Chronic Liver Disease Questionnaire | Baseline (Day 1) and Study completion (8 weeks) |
Not provided
Inclusion Criteria:
- Age >18 and less than or equal to 70 years Liver Cirrhosis Child Pugh Class A or B If required, primary or secondary Variceal prophylaxis in place
Exclusion Criteria:
- Post-liver transplantation Hepatocellular carcinoma beyond transplant criteria Active non-hepatocellular carcinoma malignancy Significant cardiac disease Hemoglobin (<80 g/L) Oxygen saturation at rest <95% Known myopathy Chronic renal failure on dialysis Physical impairment making it impossible to ride an exercise bike or treadmill Orthopedic abnormality preventing exercise training HIV infection Patient unwilling to consent to study Child Pugh class C
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Alberta, Mazankowski Heart Institute | Edmonton | Alberta | T6G2B1 | Canada |
Not provided
| Label | URL |
|---|---|
| MedlinePlus | View source |
| MedlinePlus Cirrhosis | View source |
| MedlinePlus Exercise and Physical Fitness |
Not provided
Not provided
| ID | Term |
|---|---|
| D005355 | Fibrosis |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Change in muscle oxygen extraction and consumption as measured by MRI | Baseline (day 1) and study completion (8 weeks) |
| U.S. FDA Resources | View source |