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Cirrhosis is associated with a reduction in muscle mass and exercise capacity. This has an impact on morbidity and mortality. Regular aerobic exercise training is a proven effective therapy to improve exercise capacity in healthy and clinical populations. The effect of this training has not yet been evaluated in the decompensated cirrhosis patient population. The safety of this intervention also requires further study. Using a randomized controlled design, the investigators aim to determine the safety and efficacy of eight weeks of aerobic exercise training on aerobic capacity, functional performance, and muscle mass in decompensated cirrhosis patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Aerobic Exercise | Experimental | Supervised aerobic training 3 times per week for 8 weeks (30-60 minute sessions) |
|
| Usual Care Group | Placebo Comparator | These patients will continue with their normal daily activity ad will not be provided with supervised aerobic exercise training during the study period. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Aerobic Exercise | Behavioral | Aerobic exercise |
| |
| No Intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Change in peak exercise pulmonary oxygen uptake (peak V02) | Baseline (day1) and Study End (8 weeks) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in muscle mass as measured by thigh ultrasound | Baseline (day 1) and Study End (8 weeks) | |
| Change in quality of life-Chronic Liver Disease Questionnaire | Baseline (day1) and Study End (8 weeks) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mark Haykowsky, PhD | University of Alberta | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Alberta, Mazankowski Heart Institute | Edmonton | Alberta | T6G2B1 | Canada |
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| ID | Term |
|---|---|
| D005355 | Fibrosis |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| Behavioral |
No Intervention |
|