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| Name | Class |
|---|---|
| University Hospital Bratislava | OTHER |
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The purpose of this study is to determine specific changes in muscle secretory profile (myokines, miRNA) in association with neurodegenerative disease progression and metabolic dysfunction. Next the investigators would like to determine the shift in the muscle secretory activity induced by regular exercise intervention, which the investigators think could be translated into the beneficial changes in clinical phenotypes, determined by neuroimaging, cognitive function tests and metabolic phenotyping.
Standard Operating Procedures for patient recruitment, data collection, data management, data analysis routinely used in University Hospital Bratislava and in Institute of Experimental Endocrinology Slovak Academy of Sciences will be employed.
Statistical analysis will be employed to address the primary and secondary objectives, as specified in the study protocol.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| '3 months exercise intervention program' | Experimental | all participants will be subjected to 3 months supervised exercise intervention programme |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 3 months exercise intervention program | Behavioral | 3 months exercise intervention program which is given 3-times per week, 60 min session duration, 65-75% repetition maximum or heart rate maximum, combined strength & aerobic exercises |
| Measure | Description | Time Frame |
|---|---|---|
| muscle microRNAs and myokines | We will determine muscle bioactive secretory products (myokines & miRNAs) that are regulated by acute bout of exercise in patients with neurodegenerative disease as well as in sedentary age, gender and BMI matched controls in association with their metabolic phenotype. | up to 24 months |
| whole body energy metabolism | changes in whole body energy metabolism will be determined with indirect calorimetry. & oral glucose tolerance test | up to 24 months |
| cognitive function | exercise related changes in cognitive & motoric functions will be determined with the aid of questionaires, and proton (1H)-magnetic resonance spectroscopy - brain imaging and spectroscopy | up to 24 months |
| motoric function | Proton (1H)-magnetic resonance spectroscopy - brain imaging and spectroscopy, motoric - balance testing | up to 30 months |
| Measure | Description | Time Frame |
|---|---|---|
| Muscle functional tests | Dynamometry will be used to determine maximal voluntary contraction force and the rate of force development, and Phosphorus (31P)-magnetic resonance spectroscopy to measure muscle metabolism in vivo. | up to 30 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Peter Valkovic, MD, PhD | University Hospital Bratislava | Study Chair |
| Stanislav Sutovsky, MD, PhD | University Hospital Bratislava | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Univeristy Hospital in Bratislava | Bratislava | 81369 | Slovakia | |||
| Inst. Exp. Endocrinology Slovak Acad Sci |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29312123 | Derived | Krumpolec P, Vallova S, Slobodova L, Tirpakova V, Vajda M, Schon M, Klepochova R, Janakova Z, Straka I, Sutovsky S, Turcani P, Cvecka J, Valkovic L, Tsai CL, Krssak M, Valkovic P, Sedliak M, Ukropcova B, Ukropec J. Aerobic-Strength Exercise Improves Metabolism and Clinical State in Parkinson's Disease Patients. Front Neurol. 2017 Dec 22;8:698. doi: 10.3389/fneur.2017.00698. eCollection 2017. |
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| Bratislava |
| 83306 |
| Slovakia |
| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| D000544 | Alzheimer Disease |
| D010300 | Parkinson Disease |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D024801 | Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D001519 | Behavior |
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