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| Name | Class |
|---|---|
| Dairy Farmers of Canada | OTHER |
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The purpose of this study is to investigate whether combining interval training with skim milk supplementation will result in improved glucose control and markers of cardiovascular health in people with type 2 diabetes. Participants will complete supervised interval training three times a week over a 12 week training period while consuming skim-milk, whey/casein protein drink, or a placebo beverage that does not contain any calories or vitamins/minerals immediately and 1 hour after each training session. After twelve weeks participants will repeat baseline tests to examine any effects of the intervention on their glucose control, fitness, blood vessel function, body composition, and blood markers of inflammation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Macronutrient isoenergetic control | Active Comparator | Participants will also engage in twelve weeks of high intensity interval training with consumption of one serving (250 mL) of macro nutrient matched isoenergetic control (whey/casein protein and dextrose/lactose) consumed immediately and 1 h after each training session |
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| Skim Milk | Experimental | Participants will also engage in twelve weeks of High intensity interval training with consumption of one serving (250 mL) of fat-free fluid milk immediately and 1 h after each training session |
|
| Placebo | Placebo Comparator | Participants will also engage in twelve weeks of high intensity interval training with consumption of one serving (250 mL) of placebo (water) consumed immediately and 1 h after each training session. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Skim Milk | Dietary Supplement | 250 ml skim milk will be consumed by participants immediately and 1 hour after each of the 36 sessions of high-intensity interval training over a 12 week period. |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in glycemic control assessed by continuous glucose monitoring at end of week 12 of intervention | Baseline, Week 12. |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in hemoglobin A1C percentage at end of week 12 of intervention. | Baseline, Week 12. | |
| Change from baseline in fasting plasma glucose concentration at end of week 12 of intervention. | Baseline, Week 12. |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in fasting plasma non esterified free fatty acid concentration at end of week 12 of intervention. | Baseline, Week 12 | |
| Change from baseline in systolic blood pressure at end of week 12 of intervention. | Baseline, Week 12 |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jonathan P Little, PHD | University of British Columbia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of British Columbia, Okanagan. | Kelowna | British Columbia | V1V 1V7 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29198993 | Derived | Francois ME, Pistawka KJ, Halperin FA, Little JP. Cardiovascular benefits of combined interval training and post-exercise nutrition in type 2 diabetes. J Diabetes Complications. 2018 Feb;32(2):226-233. doi: 10.1016/j.jdiacomp.2017.10.002. Epub 2017 Nov 29. |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D000072696 | High-Intensity Interval Training |
| D014867 | Water |
| D011506 | Proteins |
| ID | Term |
|---|---|
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
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| High intensity interval training | Behavioral | All participants will undergo a 12 week high intensity interval training program consisting of 3 supervised sessions a week of 4-10 x 1 min high intensity interval alternating with 1 min of recovery. |
|
| Placebo | Other | 250 mL water will be consumed by participants immediately and 1 hour after each of the 36 sessions of high-intensity interval training over a 12 week period. |
|
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| Macronutrient isoenergetic control | Dietary Supplement | 250 mL of protein+cho matched drink will be consumed by participants immediately and 1 hour after each of the 36 sessions of high-intensity interval training over a 12 week period. |
|
|
| Change from baseline in fasting plasma insulin concentration at end of week 12 of intervention. | Baseline, Week 12. |
| Change from baseline in flow mediated dilation of brachial artery at end of week 12 of intervention. | Baseline, Week 12. |
| Change from baseline in peak oxygen uptake as a measure of aerobic fitness at end of week 12 of intervention. | Baseline, Week 12 |
| Change from baseline in diastolic blood pressure at end of week 12 of intervention. | Baseline, Week 12. |
| Change from baseline in circulating inflammatory cytokines at end of week 12 of intervention. | Baseline, Week 12. |
| Change from baseline in body composition as measured by dual absorbancy x ray at end of week 12 of intervention. | Baseline, Week 12. |
| Change from baseline in task switching capabilities at end of week 12 of intervention. | Baseline, Week 12. |
| D004700 | Endocrine System Diseases |
| D009142 |
| Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
| D006878 | Hydroxides |
| D000468 | Alkalies |
| D007287 | Inorganic Chemicals |
| D000838 | Anions |
| D007477 | Ions |
| D004573 | Electrolytes |
| D010087 | Oxides |
| D017601 | Oxygen Compounds |
| D000602 | Amino Acids, Peptides, and Proteins |