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The purpose of this study is to determine whether there is a quantitative relationship between brain processes seen by a MRI and visual deficits caused by mild to moderate traumatic brain injuries (mTBI).
Participants with mTBI, as well as healthy control participants, will be invited to participate in up to two study visits. Both visits will occur at the University of Minnesota's Center for Magnetic Resonance Research (CMRR). The first study visit will entail (1) interviews to determine the presence of (and, if present, the severity of) oculomotor difficulties such as convergence insufficiency, and (2) behavioral measures (e.g., visually track a moving dot) to assess skill at allocating spatial attention. For participants who have not before participated in an MRI study at the CMRR, a 15-minute scan to acquire research-quality anatomical images of the brain will be acquired at the end of the first visit. A subset of the approximately 88 participants who participate in Visit 1 will be invited to participate in Visit 2. Visit 2 will be dominated by a 90-minute scanning session in the 7 Tesla scanner, during which participants will perform a 10-minute spatial attention task and a 10-minute eye movement task, and high-resolution diffusion tensor imaging data will be acquired while participants enjoy the movie of their choice in the scanner.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | no history of TBI or neurologic disorder | ||
| mTBI | documented past mild to moderate TBI |
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| Measure | Description | Time Frame |
|---|---|---|
| oculomotor performance | Oculomotor performance will be measured with behavioral questionnaires, eye-charts, and computerized eye-tracking while subjects perform saccades and smooth pursuit motions. | study enrollment / baseline |
| Measure | Description | Time Frame |
|---|---|---|
| frontoparietal priority maps | Functional MRI data will be collected at 7 Tesla while subjects perform spatial attention and eye movement tasks. | baseline |
| white matter integrity | Diffusion tensor imaging data will be acquired at 7 Tesla and analyzed in a priori regions of interest adjacent to frontal and parietal functional regions of interest. |
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Inclusion Criteria:
Exclusion Criteria:
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Participants with mTBI who have previously participated in MRI studies; preference will be given to individuals with visual complaints such as blurred or double vision or headaches while reading. Participants with no history of TBI and no visual complaints will also be recruited into a control group.
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| Name | Affiliation | Role |
|---|---|---|
| Cheryl A Olman, PhD | University of Minnesota | Principal Investigator |
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| ID | Term |
|---|---|
| D000070642 | Brain Injuries, Traumatic |
| D015835 | Ocular Motility Disorders |
| ID | Term |
|---|---|
| D001930 | Brain Injuries |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| baseline |
| D006259 |
| Craniocerebral Trauma |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |
| D003389 | Cranial Nerve Diseases |
| D005128 | Eye Diseases |