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| ID | Type | Description | Link |
|---|---|---|---|
| W81XWH-08-1-0725 | Other Grant/Funding Number | USA Med Research and Materiel Command |
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This project aims to study the prognostic ability of various MRI imaging markers in the evaluation of TBI patients. Cognitive, social, and occupational recovery will be measured at each time point, and compared to MRI findings. Healthy volunteers will serve as a comparison to the TBI patients.
It is hypothesized that novel MRI markers of metabolism, hemodynamics, functional connectivity, and tissue microstructure will be related to the clinical status of the patient, as well as their social and occupational outcomes.
The goal of this study is to identify advanced magnetic resonance imaging markers that can serve as a prognostic marker in the evaluation and management of traumatic brain injury patients.
Magnetic resonance imaging and cognitive testing (when possible) will be performed in the acute (within 10 days following injury), and recovery stages (about 1 month, about 6 months,and about 18 months). The relationship between the advanced magnetic resonance imaging markers and the clinical condition of the patient will be evaluated at each time point to determine which combination of imaging markers best describe the current clinical status of the patient and which markers best predict a patient's outcome status.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Severe Traumatic Brain Injury Group | The severe traumatic brain injury group are patients admitted to the study with an admission GCS between 3 and 8. | ||
| Moderate Head Injury Group | The moderate head injury group are patients admitted to the study with an admission GCS from 9 to 12. | ||
| Mild Head Injury Group | The mild head injury group are patients admitted to the study with an admission GCS from 13 to 15. | ||
| Healthy Volunteer Group | Healthy volunteers will be selected to match the age distribution of the TBI groups. They must be absent of any abnormal radiological findings. |
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| Measure | Description | Time Frame |
|---|---|---|
| Identification of advanced MR imaging markers | Systematically study the imaging markers obtained from novel MRI techniques (diffusion tensor imaging (DTI), susceptibility-weighted imaging (SWI), MR spectroscopy, resting state MRI, and arterial spin labeling) and assess the markers for sensitivity. | 18 months post-injury |
| Measure | Description | Time Frame |
|---|---|---|
| level of cognitive function | 18 months post-injury | |
| extent of disability | 18 months post-injury | |
| level of orientation |
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Inclusion Criteria:
Exclusion Criteria:
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Patients admitted with head trauma ranging from mild to severe.
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| Name | Affiliation | Role |
|---|---|---|
| Rao P Gullapalli, PhD | University of Maryland Medical School | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Maryland Medical Center | Baltimore | Maryland | 21201 | United States |
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| ID | Term |
|---|---|
| D000070642 | Brain Injuries, Traumatic |
| ID | Term |
|---|---|
| D001930 | Brain Injuries |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| 18 months post-injury |
| level of functional independence | 18 months post-injury |
| D006259 |
| Craniocerebral Trauma |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |