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| Name | Class |
|---|---|
| University of Campinas, Brazil | OTHER |
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The purpose of the study was to investigate how Brazilian fruits peel affect acute/postprandial glucose and insulin responses, inflammatory markers, appetite control peptides, antioxidative capacity, as well as subjective appetite ratings (VAS-visual analogue scales) in healthy volunteers. We hypothesize that certain Brazilian fruits peel added to a standardized meal will improve postprandial glucose tolerance and other metabolic biomarkers in healthy volunteers, compared with a similar meal without the corresponding plant materials.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control drink | Placebo Comparator | 300 ml control drink containing equal amount of total fiber and pectine as Brazilian fruit drink, acute study / one time administration |
|
| Brazilian fruit peel | Experimental | 300 ml test drink containing Brazilian fruit peel flour, acute study / one time administration |
|
| Negative control drink | Placebo Comparator | 300 ml control drink without containing amount of total fiber and pectine as Brazilian fruit drink, acute study / one time administration |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Control drink | Dietary Supplement | As a control, subjects are asked to consume 300 ml control drinks containing equal amount of total fiber and pectine as Brazilian fruit drink. Following 10 min. beverage consumption, subjects will be given standardized breakfast corresponding to 50 g carbohydrate. |
| Measure | Description | Time Frame |
|---|---|---|
| Changing on blood glucose concentration after treatment with brazilian fruits peel | The capillary blood samples will be taken for blood glucose analysis | Prior to the initial intervention at 0 min and after intervention at 15, 30, 45, 60, 90, 120, 180 min |
| Measure | Description | Time Frame |
|---|---|---|
| Changing on subjective appetite ratings after treatment with Brazilian fruits peel | Appetite will be assessed using standard subjective 100 mm VAS (visual analogue scale) at time intervals throughout each visit | Prior to the initial intervention at 0 min and after intervention at 15, 30, 45, 60, 90, 120, 180 min. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Elin Östman, PhD | Lund University | Principal Investigator |
| Glaucia Lima, MSc | Lund University | Study Chair |
| Yoghatama Cindya Zanzer, MSc | Lund University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Antidiabetic Food Centre (Medicon Village) - Lund University | Lund | Skåne County | 221 00 | Sweden |
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| ID | Term |
|---|---|
| D024821 | Metabolic Syndrome |
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| Brazilian fruit peel flour | Dietary Supplement | In this study, subjects are asked to consume 300 ml beverage drinks contain certain amounts of Brazilian fruit peel flour. Following 10 min. beverage consumption, subjects will be given standardized breakfast corresponding to 50 g carbohydrate. |
|
| Negative control drink | Dietary Supplement | As a negative control, subjects are asked to consume 300 ml control drinks without containing amount of total fiber and pectine as Brazilian fruit drink. Following 10 min. beverage consumption, subjects will be given standardized breakfast corresponding to 50 g carbohydrate. |
|
| Identify plasma metabolite profile (untargeted approach) after treatment with Brazilian fruits peel |
Metabolite profile will be analyzed using Liquid Chromatography-Mass Spectrometry based methods |
| Prior to the initial intervention at 0 min and after intervention at 60, 90, 120, 180 min. |
| Changing on insulin after treatment with Brazilian fruits peel | The venous serum blood samples will be taken for insulin analysis | Prior to the initial intervention at 0 min and after intervention at 15, 30, 45, 60, 90, 120, 180 min. |
| Changing on inflammatory markers (i.e. interleukin-6, interleukin-8, tumor necrosis factor-alpha, necrosis factor kappa-beta, adiponectin and C-reactive protein) after treatment with Brazilian fruits peel | The venous serum blood samples will be taken for inflammatory markers analysis | Prior to the initial intervention at 0 min and after intervention at 15, 30, 45, 60, 90, 120, 180 min. |
| Changing on appetite markers (i.e. ghrelin, cholecystokinin, glucagon-like peptide-1, gastric inhibitory polypeptide, peptide YY, amylin, pancreatic polypeptide) after treatment with Brazilian fruits peel | The venous serum blood samples will be taken for appetite markers analysis | Prior to the initial intervention at 0 min and after intervention at 15, 30, 45, 60, 90, 120, 180 min. |
| D009750 |
| Nutritional and Metabolic Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |