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Recruitment of 28 subjects that will be randomized to consume fruit or nuts as snacks between regular meals for two months. Laboratory tests for cardiovascular risk factors, metabolic rate, liver steatosis and physical activity are investigated ahead of start of the study and at the end of the trial period och two months. Participants will be allowed to buy fruits or nuts on their own but to keep track (diaries) of the amount consumed. They will be reimbursed for the costs of the snacks.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| fruit | Active Comparator | Participants are given +7kCal/kg body weight of fruit to be eaten as snack in between regular meals |
|
| nuts | Active Comparator | Participants are given +7kCal/kg body weight of nuts to be eaten as snack in between regular meals |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fruits | Dietary Supplement | Randomization to extra fruit or nuts as snacks |
| |
| Measure | Description | Time Frame |
|---|---|---|
| amount of fat in the liver by magnetic resonance imaging | exact measurement of fat in the liver by liver spectroscopy | two months |
| Measure | Description | Time Frame |
|---|---|---|
| cardiovascular risk factors | Collection of markers for cardiovascular risk including glucose, insulin, lipoproteins etc. Analyses will be performed from blood samples. | two months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fredrik H Nystrom | Linköping | 58185 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26788923 | Derived | Agebratt C, Strom E, Romu T, Dahlqvist-Leinhard O, Borga M, Leandersson P, Nystrom FH. A Randomized Study of the Effects of Additional Fruit and Nuts Consumption on Hepatic Fat Content, Cardiovascular Risk Factors and Basal Metabolic Rate. PLoS One. 2016 Jan 20;11(1):e0147149. doi: 10.1371/journal.pone.0147149. eCollection 2016. |
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| ID | Term |
|---|---|
| D005234 | Fatty Liver |
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
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| ID | Term |
|---|---|
| D005638 | Fruit |
| D009754 | Nuts |
| D062410 | Snacks |
| ID | Term |
|---|---|
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |
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| Nuts |
| Dietary Supplement |
|
|
| D008659 |
| Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D062407 |
| Meals |