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| Name | Class |
|---|---|
| KU Leuven | OTHER |
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The purpose of this study is to investigate the role of erythromycin, a prokinetic agent, on hunger, and the brain mechanism lying behind it.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | intravenous infusion |
|
| Erythromycin | Experimental | intravenous infusion |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Erythromycin | Drug |
| ||
| Placebo |
| Measure | Description | Time Frame |
|---|---|---|
| Functional brain images | The functional brain images will be taken via functional magnetic resonance imaging (fMRI), and be analysed via a software called SPM. | 40 min after intervention |
| Measure | Description | Time Frame |
|---|---|---|
| hunger scores | The hunger scores will be taken every 10 minutes since the scan starts via a 10 cm visual analogue scale. | every 10 minutes since the scan starts |
| gut hormones | Peripheral blood samples will be taken every 10 min since the scan starts until the endpoint of the study to measure gut hormones (motilin, ghrelin, CCK, PYY, GLP-1) by radioimmuno-assay. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jan Tack | University of Leuven | Principal Investigator |
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| ID | Term |
|---|---|
| D004917 | Erythromycin |
| ID | Term |
|---|---|
| D018942 | Macrolides |
| D061065 | Polyketides |
| D007783 | Lactones |
| D009930 | Organic Chemicals |
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physiological saline |
|
| every 10 min since the scan starts |