The Effect of Motilin on the Frequency and Amount of Food Intake

Influence of Erythromycin on ad Libitum Food Intake and the Evaluation of Motilin in Food Timing in Healthy Volunteers and Patients

In this study, the investigators aimed at evaluating the role of motilin in the regulation of food intake. Motilin, a gastrointestinal hormone, is a hunger signal in healthy volunteers and is significantly increased in obese patients. Its role in food intake regulation might contribute to the pathogenesis of obesity.

Inclusion Criteria:

• BMI < 30 kg/m² for lean volunteers
• BMI > 30 kg/m² for obese volunteers
• Subject is capable and willing to give informed consent
• Female volunteers of child bearing potential must use oral, injected or implanted hormonal methods of contraception

Exclusion Criteria:

• Female volunteer is pregnant or breastfeeding
• GI diseases, major abdominal surgery
• Major psychiatric illnesses
• Volunteers that use drugs affecting the GI tract or the central nervous system
• Volunteers suffering from endocrine diseases such as diabetes, Cushing's disease, Addison's disease, hypothalamic tumor
• Volunteers that have undergone surgical procedure for weight loss