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| Name | Class |
|---|---|
| Federal University of Rio Grande do Sul | OTHER |
| Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. | OTHER_GOV |
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To compare the acute effect of soluble fiber intake from foods or supplement after a common meal on postprandial plasma glucose and insulin in patients with type 2 diabetes. The hypothesis is a meal with a high content of soluble fiber from food determines glycemic and insulinemic response similar to a meal with a high content of soluble fiber from supplement sources.
Three breakfasts (high amount of fiber from diet food sources - HFD, high amount of soluble fiber from guar gum supplement - HFS and usual amount of fiber -UF), isocaloric and similar distribution of carbohydrates, proteins and lipids, the order of breakfasts randomly determined. Meals HFD and HFS have the same amount of fiber from different sources, origin in food and supplement respectively. Meal UF consist of the same foods meal HFS, but without the use of soluble fiber supplement and white bread instead of rye bread (low fiber content in relation to meals HFD and HFS). The supplement (Sachet 5g - Fiber Mais ®: 60% guar gum and 40% inulin) will be added to the plain water to meal HFD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HFD Meal: high fiber from food | Experimental | HFD Meal: high amount of fiber from diet food sources (total fiber 9.7g; soluble fiber 5.4g) |
|
| HFS Meal: High fiber from supplement | Experimental | HFS Meal: high amount of soluble fiber from guar gum supplement (HFS; total fiber 9.1g; soluble fiber 5.4g) - Fiber Mais, Nestlé |
|
| UF Meal: usual amount of fiber | Experimental | UF Meal: usual amount of fiber (total fiber 2.4g; soluble fiber 0.8g) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| HFD Meal: High fiber from food | Other | High amount of fiber from diet food sources (HFD; total fiber 9.7g; soluble fiber 5.4g) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Area Under the Curve (AUC 0-180min) for glycemic and insulinemic responses | Prior to the initial meal A, B and C and 30, 60,120,180 minutes postmeal |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mirela J Azevedo, PhD | Hospital de Clínicas de Porto Alegre | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital de Clínicas de Porto Alegre | Porto Alegre | Rio Grande do Sul | 90035-903 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28855225 | Derived | de Carvalho CM, de Paula TP, Viana LV, Machado VM, de Almeida JC, Azevedo MJ. Plasma glucose and insulin responses after consumption of breakfasts with different sources of soluble fiber in type 2 diabetes patients: a randomized crossover clinical trial. Am J Clin Nutr. 2017 Nov;106(5):1238-1245. doi: 10.3945/ajcn.117.157263. Epub 2017 Aug 30. |
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| HFS Meal: High fiber from supplement | Dietary Supplement | High amount of soluble fiber from guar gum supplement (HFS; total fiber 9.1g; soluble fiber 5.4g) - sachet 5 g Fiber Mais, Nestlé Brasil, São Paulo, BR |
|
|
| UF Meal: usual amount of fiber | Other | Usual amount of fiber (UF; total fiber 2.4g; soluble fiber 0.8g) |
|
| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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