To evaluate the acute effect of a low and high glycemic index breakfast on the glycemic response and satiety in subjects with type 2 diabetes mellitus under intensive insulin therapy.

Inclusion Criteria:

• Subjects with type 2 diabetes mellitus diagnosis.
• Minimum period of six months under intensive insulin therapy.
• Fast insulin prescription before breakfast.
• 35 and 70 years of age.
• BMI between 25 and 39.9 Kg/m2.
• HbA1c less than or equal to 10 % (86mmol/mol)
• Menopausal women under hormone replacement therapy

Exclusion Criteria:

• Pregnant women.
• Puerperal women.
• Subjects with neurological disease, endocrine disorder no treatment, kidney disease in stage IV or V, cancer, liver disease, chronic obstructive pulmonary disease, human immunodeficiency virus.
• Subjects with history of stroke, acute myocardial infarction or gastrointestinal resection.