Investigation of Docosahexaenoic Acid (DHA) Metabolic Pathway in Human by Using 13C Labeled Molecules

Bioavailability of DHA-TG (Docosahexaenoic Triglyceride), DHA-PC (Docosahexaenoic Phosphatidylcholine) and AcedoPC (1-acetyl-2-docosahexaenoic-glycerophosphocholine) in Human

The purpose of this study is to compare three lipidic forms of DHA in their metabolic pathway in human by using 13C labeled molecules.

The circulating form of DHA plays a major role in his cerebral incorporation. The aim of this research is to confirm that some lipidic forms are best carriers for the cerebral incorporation in studying 13C-DHA distribution in plasma lipids and blood cells.

Inclusion Criteria:

• Healthy male
• Aged of 60 to 70 years
• Body Mass Index of 20 to 30 kg/m2
• Glycaemic and lipid parameters normal

Exclusion Criteria:

• Smokers more than ten cigarettes/day
• Medical history of personal or family dyslipidemia
• Medication that could interfere with lipid metabolism