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Aim: to determine the effects of DHA supplementation:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| DHA - Sunflower oil | Experimental | 400 mg DHA supplementation by day for 2 weeks then placebo for 2 weeks after a wash out period of 6 to 9 weeks |
|
| Sunflower oil - DHA | Experimental | Placebo during 2 weeks then 400 mg DHA supplementation by day for 2 weeks after a wash out period for 6 to 9 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| First period DHA | Dietary Supplement | 400 mg DHA supplementation by day for 2 weeks during the first study period |
|
| Measure | Description | Time Frame |
|---|---|---|
| Platelet function induced by collagen | 4 blood sampling are made during the time of study which expand from 10 weeks (washout period of 6 weeks) to 13 weeks (washout period of 9 weeks):
| 4 blood sampling in 10 to 13 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of cellular and plasmatic redox status | blood sampling are made during the time of study which expand from 10 weeks (washout period of 6 weeks) to 13 weeks (washout period of 9 weeks): first at the beginning of the first period second at the end of the period (2 weeks after beginning) third at the beginning of the second period fourth at the end of the period (2 weeks after beginning) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Martine LAVILLE, MD, PhD | Hospices Civils de Lyon | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospices Civils de Lyon | Bron | France | ||||
| Centre de Recherche en Nutrition Humaine (CRNH) Rhône-Alpes |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25832443 | Result | Vericel E, Colas R, Calzada C, Le QH, Feugier N, Cugnet C, Vidal H, Laville M, Moulin P, Lagarde M. Moderate oral supplementation with docosahexaenoic acid improves platelet function and oxidative stress in type 2 diabetic patients. Thromb Haemost. 2015 Aug;114(2):289-96. doi: 10.1160/TH14-12-1003. Epub 2015 Apr 2. |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| Second period DHA | Dietary Supplement | 400 mg DHA supplementation by day for 2 weeks during the second study period |
|
| 4 blood sampling in 10 to 13 weeks |
| Pierre-Bénite |
| France |
| D004700 | Endocrine System Diseases |