Effects of Docosahexaenoic Acid (DHA) on Cardiovascular Disease on Diabetic Patients

Intake of Low Dose of Docosahexaenoic Acid: Effects on Platelet Functions and Redox Status in Diabetic Patients

Aim: to determine the effects of DHA supplementation:

• on the platelet function through their aggregation and the pathway of arachidonic acid metabolism
• on redox status on cells and plasma
• on inflammation in 16 type 2 diabetic patients in a cross-over study comparing DHA (400 mg/day for 2 weeks) vs Sunflower oil (placebo). Each period is separated by a wash-out period of 6 to 9 weeks.

Inclusion Criteria:

• woman
• Type 2 diabetes
• Menopausal or aged between 55 and 75 years old
• Recent HbA1c between 6.5-10%
• Oral anti-diabetic drugs or insulin therapy
• Hypertension or antihypertensive drug

Exclusion Criteria:

• Tobacco
• Excessive drinking
• Post-menopausal hormonal treatment
• Treatment by acetylsalicylic acid, clopidogrel, gliclazide, ticlopidine, NSAID
• Secondary cardiovascular prevention
• antioxidant using
• Fish intake >2 times a week
• Anemia <10g/L
• Thrombopenia <110g/L
• Creatinine clearance <30 ml/min and/or proteinuria >1g/L