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| ID | Type | Description | Link |
|---|---|---|---|
| UCAM-2 |
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Analyze and evaluate the skeletal muscle of patients affected with hemophilia in the Region of Murcia.
Descriptive study of joint involvement in hemophilia patients with and without a history of hemarthrosis in lower limbs.
Descriptive study of alterations in the strength of the periarticular muscles of lower limbs as a result of acute conditions or the development of chronic articular sequelae.
Descriptive study of the biomechanical alterations in weight-bearing joints of lower limbs and their impact on gait in patients with hemophilia.
Descriptive study of the relationship between skeletal muscle pathology in patients with hemophilia and their perceptions of it and their quality of life.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with hemophilia | Patients with hemophilia who meet the inclusion criteria |
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| Measure | Description | Time Frame |
|---|---|---|
| Assess the range of motion | Assess the range of motion of elbow, knee and ankle (using a goniometric evaluation). | Screening visit |
| Assess the muscular strength | Assess the muscular strength of arm, thigh and leg (through measurement of muscle balance). | Screening visit |
| Assess the joint pain | Joint pain (VAS scale with the use of a pressure algometer). | Screening visit |
| Assess the variables of strength | Assessment of variables of vertical strength, medio-lateral and anterior-posterior in jump and incorporation from the sitting position. | Screening visit |
| Assess the peak force | Functional assessment of peak force, force production per unit time and subsequent stabilization in standing (in jump and in the passage from the sitting position to standing position, respectively, using a force platform). | Screening visit |
| Assess the contractile activity | Assessment of miotendinous contractile activity in the patellar tendon and Achilles, in jump (CMJ-stiffness test). | Screening visit |
| Assess the state joint | State joint (applying Hemophilia Joint Health Score questionnaire). | Screening visit |
| Measure | Description | Time Frame |
|---|---|---|
| Age, sex, weight of the patients with hemophilia | Screening visit | |
| Diagnosis, severity of hemophilia, type of treatment (prophylactic or on-demand) and inhibitors | Screening visit | |
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Inclusion Criteria:
Exclusion Criteria:
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Patients from the Murcia Regional Hemophilia Association
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| RUBÉN CUESTA-BARRIUSO, PhD | Contact | rcuesta@ucam.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universidad Católica San Antonio, Murcia | Recruiting | Murcia | Murcia | 30107 | Spain |
| Type | Date | Date Unknown |
|---|---|---|
| Release | Oct 13, 2015 | |
| Reset | Nov 13, 2015 | |
| Release | Nov 16, 2015 | |
| Reset | Dec 17, 2015 | |
| Release | Jun 29, 2016 | |
| Reset | Aug 12, 2016 | |
| Release | Aug 26, 2016 | |
| Reset | Oct 18, 2016 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Oct 7, 2015 | Yes | |||
| Oct 13, 2015 |
| ID | Term |
|---|---|
| D006467 | Hemophilia A |
| D007592 | Joint Diseases |
| ID | Term |
|---|---|
| D025861 | Blood Coagulation Disorders, Inherited |
| D001778 | Blood Coagulation Disorders |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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| Assess the list of activities | List of activities in hemophilia (completing the autocuestionario Hemophilia Activities List). | Screening visit |
| Assess the physical performance | Perception of physical performance (with the HEP-Test-Q questionnaire) | Screening visit |
| Assess the health Profile | Health Profile (using the scale Nottingham health profile) | Screening visit |
| Assess the quality of life | Quality of life (using the SF-36 and Haemo-QoL-36 questionnaire). | Screening visit |
| Frequency of joint bleeds in the previous month and bleeding during the assessment |
| Screening visit |
| Nov 13, 2015 |
| Nov 16, 2015 | Dec 17, 2015 |
| Jun 29, 2016 | Aug 12, 2016 |
| Aug 26, 2016 | Oct 18, 2016 |
| D020147 | Coagulation Protein Disorders |
| D006474 | Hemorrhagic Disorders |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D009140 | Musculoskeletal Diseases |