Functional and Proprioceptive Status in Patients With Hemophilic Ankle Arthropathy

Functional and Proprioceptive Status in Patients With Hemophilic Ankle Arthropathy. A Case-control Study

Introduction: Hemophilic ankle arthropathy is manifested by functional degenerative alterations (muscle strength deficit, mobility and proprioception), intra-articular and chronic pain.

Design: Case-control study. Objective: To observe the differences between patients with hemophilic ankle arthropathy and their healthy peers, regarding dorsiflexion, dorsiflexion strength, biomechanical analysis of gait and balance, and functionality.

Patients: 10 patients with hemophilic ankle arthropathy and 12 healthy subjects without ankle joint damage.

Measurement instruments and study variables: dorsiflexion (range of motion), dorsiflexion strength (dynamometry), biomechanical analysis of gait and balance (RS SCAN® model platform), and functionality (2 Minute Walk Test).

Expected results: Analyze the main differences and their relationship based on the clinical and independent variables of patients with hemophilia, compared to their healthy peers.

Inclusion Criteria:

• Patients diagnosed with hemophilia A and B.
• Over 18 years.
• With medical diagnosis of ankle arthropathy.
• With clinical evaluation by Hemophilia Joint Health Score.
• In prophylactic treatment or on demand with FVIII / FIX concentrates for coagulation.
• No previous hemarthrosis of the ankles in the 3 months prior to evaluation.

Exclusion Criteria:

• Patients with inhibitors (antibodies against FVIII or FIX).
• Patients with neurological or cognitive disorders that prevent the understanding of questionnaires and physical tests.
• Failure to sign the informed consent document