The Dose-Response Relationship of Rocuronium in Patients Taking Pyridostigmine

The Dose-response Relationship of Rocuronium in Patients Taking Pyridostigmine Preoperatively Compared With Age and Sex Matched Controls

Pyridostigmine is a medication that is used in certain heart rate and blood pressure conditions. This medication, as a side effect, is known to also cause changes in the junction between a nerve and muscle. The changes caused at the nerve muscle junction by pyridostigmine could alter the effect of muscle relaxants (a medication used during surgery and anesthesia). The investigators are conducting this study to see whether patients taking pyridostigmine are more or less sensitive to rocuronium (a muscle relaxing medication used during surgery).

No subjects enrolled. No data collected.

Inclusion Criteria:

• Patients who take pyridostigmine for any reason or those who are matched by age, sex and weight to subjects taking pyridostigmine
• Patients who will be administered rocuronium during elective procedures as standard clinical care.

Exclusion Criteria:

• Allergy to rocuronium
• Known neuromuscular disorder, patients suffering from myasthenia gravis
• Subjects taking medications known to impact neuromuscular transmission (ex. gentamicin).