Magnesium Sulphate and Rocuronium in Patients Over 60

Effects of Magnesium Sulphate on the Pharmacodynamics of Rocuronium in Patients 60 Years or Older: Randomised and Double-Blind Study

The purpose of this study is to evaluate the effects of MgSO4 administration on the pharmacodynamics of rocuronium in patients with 60 or more years of age.

Inclusion Criteria:

• 60 years or older
• ASA physical status I-III
• Scheduled for elective oncologic head and neck surgery

Exclusion Criteria:

• Severe renal insufficiency (calculated creatinine clearance < 30 ml/min)
• Pre-operatory serum magnesium values > 2.5 mEq/l
• Patients receiving medications known to affect neuromuscular function (furosemide, aminoglycoside, anticonvulsivants, calcio channel blocker, litium, azatioprine, cyclofosfamide)