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This study aims to evaluate effects of magnesium sulfate on onset and duration of low dose rocuronium, intubation condition and surgical condition.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| standard dose rocuronium group | Active Comparator | pretreatment of saline 100ml and rocuronium 0.6 mg/kg |
|
| low dose rocuronium group | Active Comparator | pretreatment of saline 100ml and rocuronium 0.45 mg/kg |
|
| low dose rocuronium plus magnesium group | Active Comparator | pretreatment of magnesium sulfate 30 mg/kg and rocuronium 0.45 mg/kg |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| magnesium sulfate 30 mg/kg | Drug | Patients in each group received the magnesium sulfate 30 mg/kg for 2 min in 0.9% normal saline (total volume 100 ml) intravenously for 5 min before induction of anesthesia |
| Measure | Description | Time Frame |
|---|---|---|
| onset time of rocuronium | from injection of rocuronium to T1 suppression more than 95% up to 10 minutes | from injection of rocuronium to T1 suppression more than 95% up to 10 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| maximal suppression time and duration of rocuronium | time from the injection of rocuronium to T1 maximal suppression time and reversal of T1 25% up to 1 hours |
| Measure | Description | Time Frame |
|---|---|---|
| intubation condition | We scored intubation condition on the basis of 4 items, laryngoscopy, vocal cord position, moving of limbs, and coughing. | intubation condition during induction of anesthesia up to 10 minutes |
| surgical condition |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sang Hwan Do | Seoul National Univ. Bundang Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National Univ. Bundang Hospita | Seongnam-si | Gyeonggi-do | 463-707 | South Korea |
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| ID | Term |
|---|---|
| D008278 | Magnesium Sulfate |
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D017616 | Magnesium Compounds |
| D007287 | Inorganic Chemicals |
| D013431 | Sulfates |
| D013464 | Sulfuric Acids |
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| saline | Drug | Patients in each group received 0.9% normal saline (total volume 100 ml) alone intravenously for 5 min before induction of anesthesia |
|
to score a surgical condition according to 7 point likers scale
| intraoperative surgical condition |
| postoperative sore throat | postoperative sore throat up to 4 hours |
| D013456 |
| Sulfur Acids |
| D013457 | Sulfur Compounds |
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D017670 | Sodium Compounds |