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This study aims to evaluate effects of magnesium sulfate on onset and duration of low dose rocuronium, intubation condition and surgical condition in patients undergoing laparoscopic cholecystectomy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Standard dose Rocuronium | Active Comparator | Pretreatment of saline 100ml then giving Rocuronium 0.6 mg/kg at induction of anesthesia. |
|
| Low dose Rocuronium | Active Comparator | Pretreatment of saline 100ml then giving Rocuronium 0.45 mg/kg at induction of anesthesia. |
|
| Low dose Rocuronium + Magnesium Sulfate | Active Comparator | Pretreatment of Magnesium sulfate 30 mg/kg then giving Rocuronium 0.45 mg/kg at induction of anesthesia. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Magnesium Sulfate | Drug | Patients in each group receive Magnesium sulfate 30 mg/kg in 0.9% normal saline (total volume 100 ml) intravenously for 5 min before induction of anesthesia |
| Measure | Description | Time Frame |
|---|---|---|
| The time of onset the action of Rocuronium | by using the TOF watch nerve stimulator | Time from injection of Rocuronium till T1 suppression more than 95% up to 10 minutes. |
| The time at which Maximal suppression | by using the TOF watch nerve stimulator | Time from the injection of Rocuronium to T1 maximal suppression time (TOF=0) up to an hour. |
| Reversal of Rocuronium | by using the TOF watch nerve stimulator | Time from injection of Rocuronium till reversal of T1 (TOF=25%) around an hour after induction of anesthesia |
| Measure | Description | Time Frame |
|---|---|---|
| Intubation condition | to score intubation condition on the basis of 6 items: Jaw relaxation, laryngoscopy, vocal cord position, moving of limbs, coughing & change in heart rate. | Within 10 minutes after induction of anesthesia |
| Surgical condition |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Nawal Abdelaziz Gadelrab, Professor | Assiut University | Study Chair |
| Ola Mahmoud Wahba, Lecturer | Assiut University Hospitals | Study Director |
| Ahmed Hamada Hamed Amin, Resident | Assiut University Hospitals | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Assiut University Hospitals | Asyut | Asyut Governorate | 71121 | Egypt |
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| ID | Term |
|---|---|
| D008278 | Magnesium Sulfate |
| D012965 | Sodium Chloride |
| D000077123 | Rocuronium |
| ID | Term |
|---|---|
| D017616 | Magnesium Compounds |
| D007287 | Inorganic Chemicals |
| D013431 | Sulfates |
| D013464 | Sulfuric Acids |
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| Saline | Drug | Patients in each group receive 0.9% normal saline (total volume 100 ml) alone intravenously for 5 min before induction of anesthesia |
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| Standard dose Rocuronium | Drug | 0.6 mg/kg of Rocuronium given with induction of anesthesia |
|
| Low dose Rocuronium | Drug | 0.45 mg/kg of Rocuronium given with induction of anesthesia |
|
to score a surgical condition according to 7 point likert scale
| During surgery |
| D013456 |
| Sulfur Acids |
| D013457 | Sulfur Compounds |
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D017670 | Sodium Compounds |
| D000732 | Androstanols |
| D000731 | Androstanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |