MgSO4 Combined With Rocuronium Priming

MgSO4 Combined With Rocuronium Priming

Priming with either rocuronium or MgSO4 is known to accelerate the effect of rocuronium on muscle relaxation. The purpose of this study is to define the effect of MgSO4 on the rocuronium-priming.

Acceleration of muscle relaxation is beneficial in rapid-sequence intubation. If MgSO4 combined with priming is efficient in accelerating muscle relaxation, it would be an interesting alternative to rapid-sequence intubation.

Inclusion Criteria:

• patients of ASA Ⅰ-Ⅱ
• aged 18~65
• scheduled to undergo elective surgery under general anesthesia

Exclusion Criteria:

• risk of pulmonary aspiration
• anticipated airway difficulty
• reactive airway disease
• allergic to study drugs
• neuromuscular / cardiovascular/ renal/ hepatic disease
• atrioventricular conduction disturbance
• BMI < 18.5 or > 24.9
• chronic treatment with calcium channel blocker
• medications which affect muscle relaxation