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Dexmedetomidine is a kind of high selectivity alpha 2 agonists adrenaline, can inhibit the activity of sympathetic nerve, alleviate pain,and improve cardiovascular stability in the operation period. Dexmedetomidine have influence on perioperative stress response and immune function,but it is not clear.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| N1 group: Isoflurane & saline | Active Comparator | for normal patients: inhale Isoflurane + the same volume of saline during operation |
|
| N2 group: Isoflurane & Dexmedetomidine | Experimental | for normal patients: inhale Isoflurane + intravenous pumping Dexmedetomidine during operation |
|
| D1 group: Isoflurane & saline | Active Comparator | for diabetes patients: inhale Isoflurane + the same volume of saline during operation |
|
| D2 group: Isoflurane & Dexmedetomidi | Experimental | for diabetes patients: inhale Isoflurane + intravenous pumping Dexmedetomidine during operation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| general anesthesia induction | Drug | general anesthesia induction: midazolam 0.1mg/Kg, sufentanil 1ug/Kg, cisatracurium 0.15mg/Kg, and then immediatly administrate etomidate 0.2 mg/Kg |
| Measure | Description | Time Frame |
|---|---|---|
| blood glucose | measure blood glucose at 3 time points,the day before surgery,Intraoperative(1 hour after surgery begain),one day after surgery(24 hours after surgery); examine the concentration of blood glucose in serum. | from the day before surgery to 24 hours after surgery |
| level of blood insulin | measure the level of blood insulin at 3 time points,the day before surgery,Intraoperative(1 hour after surgery begain),one day after surgery(24 hours after surgery); use ELISA to examine the concentration of blood insulin in serum. | from the day before surgery to 24 hours after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| vital signs | measure the blood pressure(BP),heart rate(HR) and oxygen saturation(SpO2) in the perioperative period | duration of perioperative period |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hongtao Liu | Contact | 13572225310 | lannylouis@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| SecondXianJiaotongU | Recruiting | Xi’an | Shanxi | China |
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| Isoflurane | Drug | inhale Isoflurane 1.5MAC |
|
| Dexmedetomidine | Drug | anesthesia induction period: intravenous pumping Dexmedetomidine 4ug/Kg/h; after 10 minutes,turn to 0.4ug/Kg/h. |
|
| normal saline | Drug | the same volume of saline + Isoflurane during operation |
|
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D007530 | Isoflurane |
| D020927 | Dexmedetomidine |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D008738 | Methyl Ethers |
| D004987 | Ethers |
| D009930 | Organic Chemicals |
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
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