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The purpose of this study is to identify the effects of different doses of dexmedetomidine on postoperative cognitive dysfunction in elderly hypertensive patients
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A, dexmedetomidine , 0.3µg.kg-1.h-1 | Experimental | Continuous pump infusion dexmedetomidine with loading dose at 0.8µg.kg-1 over 10 minutes,followed Continuous pump infusion dexmedetomidine at 0.3µg.kg-1.h-1 until 30 minutes before end of operation |
|
| Group B,dexmedetomidine , 0.5µg.kg-1.h-1 | Experimental | Continuous pump infusion dexmedetomidine with loading dose at 0.8µg.kg-1 over 10 minutes,followed continuous pump infusion dexmedetomidine at 0.5µg.kg-1.h-1 until 30 minutes before end of operation |
|
| Group C ,normal saline | Placebo Comparator | Normal saline infusion will be given with the same infusion volume as group A and B |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| dexmedetomidine | Drug | Experimental: Group A, Continuous pump infusion dexmedetomidine with loading dose at 0.8µg.kg-1 over 10 minutes,followed continuous pump infusion dexmedetomidine at 0.3µg.kg-1.h-1 until 30 minutes before end of operation |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline to postoperation in cognitive function | Mini-mental State Examination | One day before operation,third day after operation,sixth day after operaion |
| Change from baseline to postoperation in recent memory | Rey Auditory Verbal Learning Test | One day before operation,third day after operation,sixth day after operation |
| Change from baseline to postoperation in visual space and directional force | Trail Making Test A,Trail Making Test B | One day before operation,third day after operation,sixth day after operaion |
| Change from baseline to postoperation in attention | Digit Span Test | One day before operation,third day after operation,sixth day after operaion |
| Change from baseline to postoperation in pain scores | Visual analog scales | One day before operation,third day after operation,sixth day after operation |
| Change from baseline to postoperation in depression scale | Beck Depression Inventory | One day before operation,third day after operation,sixth day after operation |
| Measure | Description | Time Frame |
|---|---|---|
| The duration of operation | From begining of cutting skin to the end of skin closure,an expected average of 3 hours | |
| The blood volume during the operation | From begining of cutting skin to the end of skin closure,an expected average of 3 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| dexmedetomidine | Drug | Group B, Continuous pump infusion dexmedetomidine with loading dose at 0.8µg.kg-1 over 10 minutes,followed continuous pump infusion dexmedetomidine at 0.5µg.kg-1.h-1 until 30 minutes before end of operation |
|
| normal saline | Drug | Group C , Normal saline infusion will be given with the same infusion volume as group A and B |
|
| midazolam,fentanyl,etomidate,Cisatracurium besylate | Drug | Anesthesia induction : 0.05 mg.kg-1 midazolam,4~5μg.kg-1 fentanyl,1.0~1.5mg.kg-1etomidate and 0.15 mg.kg-1Cisatracurium besylate |
|
| cisatracurium besylate,propofol,remifentanil,sevoflurane | Drug | Maintenance of anesthesia :Continuous pump infusion 0.05~0.1mg.kg-1.h-1cisatracurium besylate,4~8mg.kg-1.h-1propofol,0.1~0.2μg.kg-1.min-1 remifentanil and sevoflurane inhalation with 0.6%~1.0% |
|
| The urine volume during operation | From begining of cutting skin to the end of skin closure,an expected average of 3 hours |
| The dose of drugs used during operation | The dose of ephedrine, urapidil, atropine used during operation | From begining of cutting skin to the end of skin closure,an expected average of 3 hours |
| ID | Term |
|---|---|
| D000079690 | Postoperative Cognitive Complications |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D060825 | Cognitive Dysfunction |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| D000077330 | Saline Solution |
| D008874 | Midazolam |
| C101584 | cisatracurium |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
| D001569 | Benzodiazepines |
| D001552 | Benzazepines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
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