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Dexmedetomidine's Sedative Effect on Diabetic Patient
Dexmedetomidine is a high selective α2 agonist,its sedative and analgesia feature is acclaimed. The pathogenesis of type 2 diabetes mellitus is associated with α2 excessive adrenaline receptors expression. This study is to evaluate whether the use of dexmedetomidine is helpful to Diabetic Patient through its antisympathetic effect
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dexmedetomidine | Experimental | Patients in group D will be given dexmedetomidine during anesthesia induction and maintenance phase respectively.In induction phase infuse 1μg/Kg of dexmedetomidine in 10 minutes， the speed in maintenance phase is 0.4μg/Kg.h |
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| placebo | Placebo Comparator | Patients in group P will be given normal saline during anesthesia induction and maintenance phase |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexmedetomidine | Drug | During anesthesia induction, all patients will be given propofol,fentanyl,vecuronium bromide.But before induction start in Dexmedetomidine(D) group, patient will be given dexmedetomidine 1μg/Kg for 10 minutes In anesthesia maintenance, D group will be given dexmedetomidine 0.4μg/Kg.h until 40 minutes before the end of surgery |
| Measure | Description | Time Frame |
|---|---|---|
| sedation level | Ramsay score and BIS will be recorded before medication,5 min after medication, medication ending, 5 and 10 min after medication | from 5 minutes before medication to 10 minutes after Dexmedetomidine discontinuance，length of time frame is about 2 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Heart rate | recorded at before medication,5 min after medication, medication ending, 5 and 10 min after medication, before intubation, after intubation, after skin incision,60 minutes after skin incision, after extubation,first day after operation | participants will be followed from operation day to first postoperative day，an expected average of 2 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yulong Song | Contact | 86-13519185656 |
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| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| placebo | Drug | During anesthesia induction, all patients will be given propofol,fentanyl,vecuronium bromide.But before induction start in Placebo(P) group, patient will be given placebo for 10 minutes In anesthesia maintenance, D group will be given placebo until 40 minutes before the end of surgery |
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| Mean arterial pressure | 10 min after medication, before intubation, after intubation, after skin incision,60 minutes after skin incision, after extubation,first day after operation | participants will be followed from operation day to first postoperative day，an expected average of 2 days |
| blood glucose measured by Biochemical test | it will be recorded immediately after the entrance to the operating room, before operation, 60 minutes after incision, after extubation, first day after operation | participants will be followed from operation day to first postoperative day，an expected average of 2 days |
| cortisol measured by Biochemical test | it will be recorded immediately after the entrance to the operating room, before operation, 60 minutes after incision, after extubation, first day after operation | participants will be followed from operation day to first postoperative day，an expected average of 2 days |
| insulin measured by Biochemical test | it will be recorded immediately after the entrance to the operating room, before operation, 60 minutes after incision, after extubation, first day after operation | participants will be followed from operation day to first postoperative day，an expected average of 2 days |
| adrenaline measured by Biochemical test | it will be recorded immediately after the entrance to the operating room, before operation, 60 minutes after incision, after extubation, first day after operation | participants will be followed from operation day to first postoperative day，an expected average of 2 days |
| noradrenaline measured by Biochemical test | it will be recorded immediately after the entrance to the operating room, before operation, 60 minutes after incision, after extubation, first day after operation | participants will be followed from operation day to first postoperative day，an expected average of 2 days |
| D000077324 |
| Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |