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To compare the 2 methods of weaning of nasal continuous positive airway pressure (CPAP) in premature babies born between 26 and 32 weeks
To study the weight and the post menstrual age (PMA) at the time of NCPAP wean utilizing the method of sudden wean as compared to gradual wean.
Methods: A prospective randomized trial was conducted comparing sudden weaning with gradual weaning from NCPAP in neonates with gestational age between 26 and 32 weeks. The patients were randomized to one of the two methods of weaning from NCPAP and their success was compared
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sudden wean | No Intervention | When ready Nasal Continuous Positive Airway Pressure (NCPAP) will be removed from the neonate | |
| Gradual pressure wean | Active Comparator | NCPAP will be removed by gradually decreasing pressure over 24 hours once the weaning is decided |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Gradual pressure wean | Other | NCPAP will be removed by gradually decreasing pressure over 24 hours once the weaning is decided |
|
| Measure | Description | Time Frame |
|---|---|---|
| Success of weaning on first trial off NCPAP | Completion of Nasal Continuous Positive Airway Pressure (NCPAP) treatment, expected average of 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Weight and corrected GA when come off oxygen | when off supplemental oxygen expected average of 2 weeks | |
| Weight and corrected gestational age (GA) when neonates could come off NCPAP | Completion of Nasal Continuous Positive Airway Pressure (NCPAP) treatment, expected average of 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| length of stay in the neonatal intensive care unit | when ready to be discharged, expected average of 6-8 weeks |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Shantanu Rastogi, MD | Maimonides Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Maimonides medcial center | Brooklyn | New York | 11219 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28230835 | Derived | Amatya S, Macomber M, Bhutada A, Rastogi D, Rastogi S. Sudden versus gradual pressure wean from Nasal CPAP in preterm infants: a randomized controlled trial. J Perinatol. 2017 Jun;37(6):662-667. doi: 10.1038/jp.2017.10. Epub 2017 Feb 23. |
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| ID | Term |
|---|---|
| D012128 | Respiratory Distress Syndrome |
| D047928 | Premature Birth |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D012120 | Respiration Disorders |
| D007752 | Obstetric Labor, Premature |
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| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |