A Comparison of Methods of Discontinuing Nasal CPAP in Premature Infants <30 Weeks Gestation

A Comparison of Methods of Discontinuing Nasal CPAP in Premature Infants <30 Weeks Gestation - a Feasibility Study

The purpose of this study is to determine if among infants <30 weeks gestational age on nasal continuous positive airway pressure (NCPAP), whether discontinuing CPAP after gradual reduction in continuous positive airway pressure (CPAP) pressure leads to successful weaning off CPAP when compared to discontinuing CPAP without weaning pressure.

Inclusion Criteria:

• All infants < 30 weeks by dates, on NCPAP therapy, on caffeine 10mg/kg daily
• Meet CPAP stability criteria for ≥ 12hours (CPAP 6 cm water (H2O), FiO2 </=0.25 and stable (to maintain sats 85-95%), Respiratory rate consistently less than 60, Mild to no subcostal/intercostal retractions, No Apnea or bradycardia event that requires bag mask ventilation, Less than 3 apnea/brady/desat episodes in any 1 hour period for previous 6 hours, Tolerated time off CPAP during routine CPAP care (~15 min)

Exclusion Criteria:

• Major congenital anomalies including congenital heart disease
• Anomalies that prevent discontinuation of NCPAP
• Undergoing current evaluation for and/or treatment of sepsis