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To compare the 2 methods of weaning of nasal CPAP in premature babies born at 32 weeks or less
Objective: To study the weight and the post menstrual age (PMA) at the time of nasal CPAP (NCPAP) wean utilizing the method of sudden wean as compared to gradual wean. . Methods: A prospective randomized trial was conducted comparing sudden weaning with gradual weaning from NCPAP in neonates with gestational age (GA) <32 weeks. The patients were randomized to one of the two methods of weaning from NCPAP and their success was compared.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Gradual wean from Nasal CPAP | Active Comparator | Nasal CPAP for gradual wean group it was cycled off for 3 hours alternating with 3 hours on for first 48 hours, if successful the cycle was extended to 6 hours off and 3 hours on for the next 48 hours. If the baby tolerated this regime the prongs were removed and CPAP was kept off. |
|
| Sudden wean from Nasal CPAP | No Intervention | Usual practice to wean the preterm neonates from nasal CPAP |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Gradual weaning from Nasal CPAP in preterm neonates | Procedure | Nasal CPAP for gradual wean group it was cycled off for 3 hours alternating with 3 hours on for first 48 hours, if successful the cycle was extended to 6 hours off and 3 hours on for the next 48 hours. If the baby tolerated this regime the prongs were removed and CPAP was kept off. |
| Measure | Description | Time Frame |
|---|---|---|
| Weight when preterm neonates could come off nasal CPAP | Weight when preterm neonates could come off nasal CPAP | During the initial NICU stay |
| Post-menstrual age when preterm neonates could come off nasal CPAP | Post-menstrual age when preterm neonates could come off nasal CPAP | During the initial NICU stay |
| Measure | Description | Time Frame |
|---|---|---|
| Weights when the neonates could come off oxygen | Weights when the neonates could come off oxygen | During the initial NICU stay |
| length of stay in the hospital | length of stay in the hospital |
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Inclusion Criteria:
All babies born with GA <32 weeks admitted to the neonatal intensive care units at the Maimonides Infant and Children's Hospital, between 1st January 2008 and 31st March 2009 and required to be on NCPAP for longer than 48 hours.-
Exclusion Criteria:
Those with severe congenital anomalies and chromosomal defects including congenital heart disease and neurological malformations, chest wall or airway abnormalities and lung hypoplasia, were excluded from the cohort
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| Name | Affiliation | Role |
|---|---|---|
| Shantanu Rastogi, MD | Maimonides Medical Center | Principal Investigator |
| Alok Bhutada, MD | Maimonides Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Maimonides Medical Center | Brooklyn | New York | 11219 | United States |
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| Label | URL |
|---|---|
| pubmed abstract | View source |
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| ID | Term |
|---|---|
| D014886 | Weaning |
| ID | Term |
|---|---|
| D007227 | Infant Nutritional Physiological Phenomena |
| D002664 | Child Nutritional Physiological Phenomena |
| D009747 | Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
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| During the initial NICU stay |
| Post-menstrual age when preterm neonates could come off oxygen | Post-menstrual age when preterm neonates could come off oxygen | During the initial NICU stay |
| D010829 | Physiological Phenomena |