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| ID | Type | Description | Link |
|---|---|---|---|
| 2013-002555-14 | EudraCT Number |
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The endocannabinoid (eCB) system, a neurochemical signalling system consisting of CB-receptors and their endogenous ligands, has been found to be involved in food intake of sweet and palatable foods. Activation of the eCB system increases food intake and vice versa. The mechanism behind this effect is still unknown and the current study aims at clarifying why sweet food intake increases. It is hypothesized that sweet taste intensity increases and that sweet taste is experienced as more pleasant.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| T-C-P | Experimental | Order of administrations: tetrahydrocannabinol - cannabidiol - placebo |
|
| T-P-C | Experimental | Order of administrations: tetrahydrocannabinol - placebo - cannabidiol |
|
| C - T - P | Experimental | Order of administrations: cannabidiol - tetrahydrocannabinol - placebo |
|
| C - P - T | Experimental | Order of administrations: cannabidiol - placebo - tetrahydrocannabinol |
|
| P - T - C | Experimental | Order of administrations: placebo - tetrahydrocannabinol - cannabidiol |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tetrahydrocannabinol | Drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| Relation between sweet taste intensity and liking | The main study parameter is the relation between sucrose intensity scaling (psychophysics) and liking (psychohedonics) of drinks with the different sucrose concentrations. These scores will be assessed after six participants and at end of the study. | 15 minutes after intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Ranking order of pleasantness of different drinks with different levels of sucrose. | Ranking order will be assessed after 6 participants and at end of the study | 25 minutes after intervention |
| Preferences for different kinds of foods |
| Measure | Description | Time Frame |
|---|---|---|
| Descriptives | General subject characteristics, e.g age, restrained eating score and other lifestyle and medical parameters | At inclusion of participants |
| Appetite ratings | During each test session, appetite ratings will be assessed at several time points |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Suzanne EM de Bruijn, MSc | Wageningen University | Principal Investigator |
| Gerry Jager, Dr. | Wageningen University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Wageningen University | Wageningen | Gelderland | 6703 HD | Netherlands |
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| ID | Term |
|---|---|
| D013759 | Dronabinol |
| D002185 | Cannabidiol |
| ID | Term |
|---|---|
| D002186 | Cannabinoids |
| D013729 | Terpenes |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
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| P - C - T | Experimental | Order of administrations: placebo - cannabidiol - tetrahydrocannabinol |
|
| cannabidiol | Drug |
|
|
| Placebo | Drug |
|
Preference for foods high in one of three macronutrients (carbohydrate, protein, fat) or low in energy
| 45 minutes after intervention (15 minutes after top-up dose) |
| Ad libitum intake | Ad libitum intake of a chocolate-based drink | 35 minutes after intervention (5 minutes after top-up dose) |
| Change of plasma levels of (endo-)cannabinoids and satiety hormones | One hour after intervention |
| Polymorphisms | The genetic determination of the enzymes responsible for the metabolism of THC and CBD. | At test session, i.e., 2 weeks before first intervention |
| During each test session |
| Subjective feelings | During each test sessions, participants will rate the effects of the intervention. | During each test session |
| Perception | Participants will rate the intensity of different shades of grey. | 20 minutes after intervention |
| Sweet taste intensity | Sucrose intensity of drinks (psychophysics) of drinks with different sucrose concentrations. This will be assessed after six participants and at end of the study. | 15 minutes after intervention |
| Liking of sweet taste | Liking (psychohedonics) of drinks with the different sucrose concentrations. This will be assessed after six participants and at end of the study. | 15 minutes after intervention |