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The study is designed to answer the following questions:
1) What is the effect of testosteron replacement treatment on the endothelial dysfunction.
2/ What is the effect of testosteron replacement on the bone mineral metabolism.
this is an interventional study which is examine the effect of testosteron replacement treatment on the endothelial dysfunction and bone mineral metabolism in hypogonadotropic hypogonadal patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| testosterone | Other | testosterone 250 mg injection per 3-4 weeks for 6 months |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Testosterone | Drug | Testosterone 250 mg injection per 3-4 weeks for 6 months |
|
| Measure | Description | Time Frame |
|---|---|---|
| the effect of testosteron replacement treatment on the Fibroblast Growth Factor-23. | Plasma FGF-23 levels were determined by ELISA, (Human Intact FGF-23 ELISA Kit, Inc., San Clement, CA, USA). | 6 months |
| the effect of testosteron replacement treatment on the asymmetric dimethylarginine. | Plasma ADMA levels were determined by ELISA (Immunodiagnostic, Bernheim, Germany) | 6 months |
| the effect of testosteron replacement treatment on the vitamin D levels. | Plasma 25-OH vitamin D3 levels were measured by Immuchrom kits (Hessen, Germany) using isocratic HPLC method with UV detector in Prominence HPLC system. | 6 months. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gulhane School of Medicine | Ankara | 06018 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D007006 | Hypogonadism |
| ID | Term |
|---|---|
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| D013739 | Testosterone |
| ID | Term |
|---|---|
| D000737 | Androstenols |
| D000736 | Androstenes |
| D000731 | Androstanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D045165 | Testosterone Congeners |
| D012739 | Gonadal Steroid Hormones |
| D042341 | Gonadal Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
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