Endothelial Dysfunction, Inflammation and Insulin Resistance in Congenital Hypogonadism and Effect of Testosteron Replacement Therapy

Phase 4 Study That Evaluates the Presence of Endothelial Dysfunction, Inflammation and Insulin Resistance in Male Subjects With Hypogonadotrophic Hypogonadism and Effects of Two Different Testosterone Replacement Regiments on These Parameters.

The study searched for answers to two questions

1. Is there endothelial dysfunction, inflammation and insulin resistance in patients with congenital hypogonadotropic hypogonadism?
2. What is the effect of testosterone replacement therapy on endothelial dysfunction, inflammation and insulin resistance?

Inclusion Criteria:

• Men
• Treatment naive
• Hypogonadotrophic hypogonadism

Exclusion Criteria:

• Previous history of androgen replacement
• Chronic metabolic disorders