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The aim of this study is to investigate whether a combination of intensive training of visual-spatial abilities (LOCATO task) with anodal transcranial direct current stimulation (tDCS) leads to an improvement of learning and memory in healthy young adults and to examine the underlying neuronal mechanism.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| training + sham stimulation | Sham Comparator | Combination of intensive training of visual-spatial abilities (LOCATO task) with sham stimulation |
|
| training + tDCS | Experimental | Combination of intensive training of visual-spatial abilities (LOCATO task) with transcranial direct current stimulation (tDCS) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tDCS | Device | transcranial direct current stimulation (tDCS) |
|
| Measure | Description | Time Frame |
|---|---|---|
| performance in LOCATO task (visual-spatial learning and memory) after a combination of intensive visual-spatial training and tDCS | Investigation whether the combination of intensive visual-spatial training (LOCATO task) and tDCS leads to improvement of visual-spatial learning and memory measured by the performance in LOCATO task after end of a 3 day period of training compared to sham stimulation. | immediately after end of a 3 day period of training in tDCS condition vs sham condition |
| Measure | Description | Time Frame |
|---|---|---|
| long term effects | long term effetcs measured by performance in LOCATO task after end of training and after 1 month compared to control conditions | after 1 month vs baseline |
| functional changes: Connectivity |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Agnes Flöel, Prof. Dr. | Charite University, Berlin, Germany | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Charite Universitätsmedizin Berlin | Berlin | 10117 | Germany |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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| training | Behavioral | intensive training of visual-spatial abilities (in LOCATO task) |
|
Connectivity (measured by resting-state fMRT and correlation analysis) at baseline compared to end of training
| after end of 3-day cognitive training vs baseline |
| cortical excitability | cortical excitability measured by transcranial magnetic stimulation (TMS) | at baseline |
| Quality of Life | quality of life as measured by standardized questionaire at baseline compared to quality of life measured 1 month after intervention (training and stimulation vs. training and sham-stimualtion) | after 1 month vs baseline |
| memory | memory performance tested at baseline compared to memory performance after the end of a 3-day cognitive training period and after 1 month (posttraining) in training and stimulation vs. training and sham stimulation | immediately after end of 3-day of cognitive training, after 1 month vs. baseline |
| genotyping of learning related polymorphisms | To assess predictors of positive reaction to brain stimulation, genotyping of several learning related polymorphisms will be performed (i.e., APOE, BDNF Val66Met, COMT Val158Met). | once |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |