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The aim of this study is to investigate whether a tDCS-accompanied training of audio-visual associative memory leads to a performance improvement in healthy older individuals.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Anodal tDCS + training | Experimental | Combination of intensive training of picture-word associations (Wernicko task) with anodal stimulation |
|
| Sham tDCS + training | Sham Comparator | Combination of intensive training of picture-word associations (Wernicko task) with sham stimulation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tDCS | Device |
| ||
| training |
| Measure | Description | Time Frame |
|---|---|---|
| Performance in a verbal associative learning paradigm under anodal tDCS compared to sham tDCS. | Investigation whether anodal tDCS leads to improved performance accuracy in the Wernicko task compared to sham stimulation. | Performance is assessed within 1 day immediately after training period (several learning blocks) compared to sham |
| Measure | Description | Time Frame |
|---|---|---|
| Functional connectivity predictors | Connectivity as measured by resting-state fMRI during baseline as predictors for performance and tDCS responsiveness | assessed during baseline testing |
| Structural predictors |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Agnes Flöel, Prof. Dr. | Charite University, Berlin, Germany | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Charité Universitätsmedizin Berlin | Berlin | 10117 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18303984 | Background | Floel A, Rosser N, Michka O, Knecht S, Breitenstein C. Noninvasive brain stimulation improves language learning. J Cogn Neurosci. 2008 Aug;20(8):1415-22. doi: 10.1162/jocn.2008.20098. | |
| 11856568 | Background | Breitenstein C, Knecht S. Development and validation of a language learning model for behavioral and functional-imaging studies. J Neurosci Methods. 2002 Mar 15;114(2):173-9. doi: 10.1016/s0165-0270(01)00525-8. |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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| Behavioral |
|
|
Microstructure of white matter (Fractional Anisotropy) as measured by diffusion tensor imaging during baseline as predictors for performance and tDCS responsiveness
| assessed during baseline testing |
| Genotyping of learning related polymorphisms | To assess predictors of positive reaction to brain stimulation, genotyping of several learning related polymorphisms will be performed. | assessed during baseline screening |
| Other cognitive outcomes: Attention performance | Digit span forward performance assessed before and after stimulation to test for tDCS effects on attention | Performance is assessed within 1 day before and after tDCS + training compared to sham |
| Other cognitive outcomes: working memory | Digit span backwards performance assessed before and after stimulation to test for tDCS effects on working memory | Performance is assessed within 1 day before and after tDCS + training compared to sham |
| 15808996 | Background | Breitenstein C, Jansen A, Deppe M, Foerster AF, Sommer J, Wolbers T, Knecht S. Hippocampus activity differentiates good from poor learners of a novel lexicon. Neuroimage. 2005 Apr 15;25(3):958-68. doi: 10.1016/j.neuroimage.2004.12.019. |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |