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The aim of this study is to investigate whether a combination of intensive training of visual-spatial abilities (LOCATO task) with anodal transcranial direct current stimulation (tDCS) leads to an improvement of learning and memory in healthy older adults and to examine the underlying neuronal mechanism.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| training + tDCS | Experimental | Combination of intensive training of visual-spatial abilities (LOCATO task) with transcranial direct current stimulation (tDCS) |
|
| training + sham stimulation | Sham Comparator | Combination of intensive training of visual-spatial abilities (LOCATO task) with sham stimulation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tDCS | Device | transcranial direct current stimulation (tDCS) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Performance in LOCATO task (Visual-Spatial learning and memory) after a combination of intensive visual-spatial training and tDCS | Investigation whether the combination of intensive visual-spatial training (LOCATO task) and tDCS leads to an improvement of visual-spatial learning and memory measured by performance in LOCATO task after end of a 3 day training period compared to sham stimulation. | immediately after the end of a 3 day training period in tDCS condition compared to sham condition |
| Measure | Description | Time Frame |
|---|---|---|
| long term effects | long term effects measured by performance in LOCATO task after end of training and after 1 month compared to control condition | after 1 month vs baseline |
| functional changes: Connectivity |
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Inclusion Criteria (old healthy controls):
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Agnes Flöel, Prof. Dr. | Charite University, Berlin, Germany | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Charite Universitätsmedizin Berlin | Berlin | 10117 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27047376 | Result | Antonenko D, Kulzow N, Cesarz ME, Schindler K, Grittner U, Floel A. Hippocampal Pathway Plasticity Is Associated with the Ability to Form Novel Memories in Older Adults. Front Aging Neurosci. 2016 Mar 22;8:61. doi: 10.3389/fnagi.2016.00061. eCollection 2016. | |
| 29050849 | Result | Antonenko D, Kulzow N, Sousa A, Prehn K, Grittner U, Floel A. Neuronal and behavioral effects of multi-day brain stimulation and memory training. Neurobiol Aging. 2018 Jan;61:245-254. doi: 10.1016/j.neurobiolaging.2017.09.017. Epub 2017 Sep 28. |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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| training | Behavioral | intensive training of visual-spatial abilities (in LOCATO task) |
|
Connectivity (measured by resting-state fMRT and correlation analysis) at baseline compared to end of 3 day period of training
| after end of 3-day period of training vs baseline |
| cortical excitability | measured by transcranial magnetic stimulation (TMS) at baseline | at baseline |
| Quality of life | quality of life as measured by standardized questionaire at baseline compared to quality of life measured 1 month after intervention (training and stimulation vs. training and sham-stimualtion) | after 1 month vs baseline |
| memory | memory performance tested at baseline compared to memory performance after the end of a 3-day cognitive training period and after 1 month (posttraining) in training and stimulation vs. training and sham stimulation | immediately after end of 3-day of cognitive training, after 1 month vs. baseline |
| affective state | affective state measured at baseline compared to affective state measured after the end of a 3-day cognitve training period and after 1 month (posttraining) in training and stimulation vs. training and sham stimulation | immediately after the end of 3-day cognitive training, after 1 month vs. baseline |
| genotyping of learning related polymorphisms | To assess predictors of positive reaction to brain stimulation, genotyping of several learning related polymorphisms will be performed (i.e., APOE, BDNF Val66Met, COMT Val158Met). | once |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |