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The study was conducted to investigate the effect of soluble phosphate in combination with different calcium doses on calcium and phosphorus metabolism and further physiological parameters in healthy subjects. The main aim of the study is to investigate the influence of a soluble phosphate supplementation on the fasting blood phosphate concentration and the dependency of an additional calcium intake.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| P1000/Ca0 | Experimental |
| |
| P1000/Ca500 | Experimental |
| |
| P1000/Ca1000 | Experimental |
| |
| Placebo | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| P1000/Ca0 | Dietary Supplement | 22 subjects consume for 8 weeks a beverage enriched with phosphate [1g phosphorus/d] |
|
| Measure | Description | Time Frame |
|---|---|---|
| Fasting phosphate concentration in blood | 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Calcium and phosphorus metabolism |
| 8 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Michael Glei, Prof. Dr. | Friedrich-Schiller-University Jena, Institute of Nutrition, Department of Nutritional Toxicology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Friedrich-Schiller-University Jena, Institute of Nutrition, Department of Nutritional Toxicology | Jena | Thuringia | 07743 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29452584 | Derived | Trautvetter U, Camarinha-Silva A, Jahreis G, Lorkowski S, Glei M. High phosphorus intake and gut-related parameters - results of a randomized placebo-controlled human intervention study. Nutr J. 2018 Feb 16;17(1):23. doi: 10.1186/s12937-018-0331-4. | |
| 26786148 | Derived | Trautvetter U, Jahreis G, Kiehntopf M, Glei M. Consequences of a high phosphorus intake on mineral metabolism and bone remodeling in dependence of calcium intake in healthy subjects - a randomized placebo-controlled human intervention study. Nutr J. 2016 Jan 19;15:7. doi: 10.1186/s12937-016-0125-5. |
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| ID | Term |
|---|---|
| D005419 | Flavonoids |
| ID | Term |
|---|---|
| D002867 | Chromones |
| D001578 | Benzopyrans |
| D011714 | Pyrans |
| D006573 | Heterocyclic Compounds, 1-Ring |
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| P1000/Ca500 | Dietary Supplement | 22 subjects consume for 8 weeks a beverage enriched with phosphate [1 g phosphorus/d] and calcium [0,5 g calcium] |
|
| P1000/Ca1000 | Dietary Supplement | 22 subjects consume for 8 weeks a beverage enriched with phosphate [1 g phosphorus/d] and calcium [1 g calcium] |
|
| Placebo | Dietary Supplement | all participants consume two weeks before intervention the beverage without phosphate and calcium |
|
| D006571 |
| Heterocyclic Compounds |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |