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The study was conducted to investigate the effect of vitamin d3 alone and in combination with calcium phosphate on bone metabolism and further physiological parameters in healthy subjects. It is postulated that calcium phosphate beneficially influences the bone specific action of vitamin d3.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| calcium phosphate | Experimental |
| |
| vitamin d | Experimental |
| |
| calcium phosphate and vitamin d | Experimental |
| |
| placebo | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| calcium phosphate | Dietary Supplement | 20 subjects consume for 8 weeks a bread enriched with calcium phosphate [1g calcium/d] |
|
| Measure | Description | Time Frame |
|---|---|---|
| bone resorption and bone formation markers in blood and urine | 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| concentration of minerals in blood, stool and urine | 8 weeks | |
| blood lipids | 8 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Gerhard Jahreis, Prof. Dr. | Friedrich-Schiller-University Jena, Institute of Nutrition, Department of Nutritional Physiology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Friedrich-Schiller-University Jena, Institute of Nutrition, Department of Nutritional Physiology | Jena | Thuringia | 07743 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24438153 | Derived | Trautvetter U, Neef N, Leiterer M, Kiehntopf M, Kratzsch J, Jahreis G. Effect of calcium phosphate and vitamin D(3) supplementation on bone remodelling and metabolism of calcium, phosphorus, magnesium and iron. Nutr J. 2014 Jan 17;13:6. doi: 10.1186/1475-2891-13-6. |
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| ID | Term |
|---|---|
| C020243 | calcium phosphate |
| D014807 | Vitamin D |
| ID | Term |
|---|---|
| D012632 | Secosteroids |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
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| vitamin d | Dietary Supplement | 20 subjects consume for 8 weeks a bread with vitamin d3 [10µg/d] |
|
| calcium phosphate and vitamin d | Dietary Supplement | 20 subjects consume for 8 weeks a bread enriched with calcium phosphate [1g calcium/d] and vitamin d3 (10µg/d] |
|
| placebo | Other | All participants consume two weeks before intervention a bread without calcium an vitamin d. |
|