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| Name | Class |
|---|---|
| University of Tampa | OTHER |
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We hypothesize that adenosine-5'-triphosphate (ATP) supplementation will be able to enhance motor unit recruitment while simultaneously blunting the decline in power and reaction time that is typically seen during repetitive sprints. This will give researchers a better understanding of the mechanism by which ATP supplementation can augment power, especially under high fatiguing conditions.
Healthy participants of similar training status as previously tested will be enrolled into the study. The participants will be randomly assigned to either placebo supplementation or to 400 mg ATP per day for 14 days. The supplements will be taken in the morning and the last dose will be taken 30 min prior to testing on the last day. Testing will be performed at baseline and after the 14 days of supplementation. Ten successive sprints will be conducted on the Wingate apparatus as this has been previously demonstrated to decrease muscle excitability. After the sprints, muscle excitability, reaction time, and vertical jump power will be measured. In addition a blood sample will be obtained before and after supplementation and complete blood hematology and chemistry analyses will be performed. It is expected that ATP supplementation may help maintain muscle excitability and power after the successive sprint sessions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | This arm will serve as the placebo supplementation. |
|
| ATP | Active Comparator | This arm will serve as the treatment intervention, ATP |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo | Dietary Supplement |
|
| |
| ATP |
| Measure | Description | Time Frame |
|---|---|---|
| Muscle Excitability | Muscle excitability will be measured using Delsys Wireless Electromyography (EMG) sensors. | Day 14 |
| Measure | Description | Time Frame |
|---|---|---|
| Power | Muscle power will be measured using the Wingate and vertical jump power measures. | Day 14 |
| Measure | Description | Time Frame |
|---|---|---|
| Reaction Time | Reaction time will be measured using a Dynavision apparatus. | Day 14 |
| Blood Biochemical Analyses | Blood chemistries and hematology will be measured after the 14 days of supplementation. |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| John A Rathmacher, PhD | Metabolic Technologies Inc. | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jacob M Wilson, PhD | Tampa | Florida | 33606 | United States |
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| Dietary Supplement |
400 mg of ATP |
|
|
| Day 14 |
| ID | Term |
|---|---|
| D000255 | Adenosine Triphosphate |
| ID | Term |
|---|---|
| D000227 | Adenine Nucleotides |
| D011685 | Purine Nucleotides |
| D011687 | Purines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D009711 | Nucleotides |
| D009706 | Nucleic Acids, Nucleotides, and Nucleosides |
| D012265 | Ribonucleotides |
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