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| Name | Class |
|---|---|
| Iowa State University | OTHER |
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Adenosine-triphosphate (ATP) serves as the sole energy source for muscle contraction. Therefore human performance of brief maximal exercise is limited, in part, by the availability of ATP to the contracting muscle. Because muscle ATP storage is small (enough to sustain maximal exercise for less than 1 second), factors that enhance either storage or resynthesis of ATP may have a positive impact on repeated muscle contractions. The current study will test the hypothesis that increasing ATP availability to muscle via oral supplementation will improve performance of repeated high intensity exercise as measured by a) work performed in each of the three 50 contraction fatigue tests, b) sum of total work performed, and c) percentage decrement in total work from the first to third third 50 contraction test.
To date we have studied 10 subjects who have followed through with all 3 of the original interventions (Placebo, 250 mg PeakATP/d and 400 mg PeakATP/d). Currently we have received approval and are expanding the study with 5 additional subjects who will receive the Placebo, 400 mg PeakATP/d and the 400 mg PealATP/d plus proprietary blend interventions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | Oral placebo capsules similar in color and size to the intervention |
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| PeakATP 250 | Active Comparator | Oral supplement capsules containing 250 mg/day of PeakATP |
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| PeakATP 400 | Active Comparator | Oral supplement capsules containing 400 mg/day of PeakATP |
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| PeakATP 400 plus proprietary blend | Active Comparator | Oral supplement capsules containing 400 mg/day of PeakATP plus a proprietary blend |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PeakATP 250 | Dietary Supplement | The nutritional intervention provides for oral ingestion of 250 mg PeakATP per day |
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| Measure | Description | Time Frame |
|---|---|---|
| Work Performed | The work and total work performed in 3 exercise fatigue tests given after 15 days of nutritional intervention. | Measured after 15 days of intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Decrease in work performed in each successive test | The decrease in total work performed in each of 3 successive fatigue tests will be measured and used as a measure of muscle fatigability after 15 days of nutritional intervention | Measured after 15 days of intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| John A Rathmacher, PhD | Metabolic Technologies Inc. | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Iowa State University | Ames | Iowa | 50010 | United States |
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| Placebo | Dietary Supplement | Placebo capsules that are comparable in size and color to the active comparator for blinding purposes |
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| PeakATP 400 | Dietary Supplement | The nutritional intervention provides for oral ingestion of 400 mg PeakATP per day |
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| PeakATP 400 plus proprietary blend | Dietary Supplement | The nutritional intervention provides for oral ingestion of 400 mg PeakATP per day plus a proprietary blend of additional nutrients |
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