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The aim of this study is the comparison between the effects of supplementation with omega 3 or placebo for 8 weeks in serum level of IGF-1 and IGFBP-3 and gene expression of IGF-1 in patients with cardiovascular disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CVD, Omega-3 | Active Comparator | patients with Cardiovascular disease who receive 4g/d omega-3 |
|
| CVD, Placebo | Placebo Comparator | patients with cardiovascular disease who receive 4 cap of placebo/day |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Omega-3 | Dietary Supplement | 4 cap 1 g Omega-3 per day for 2 months |
|
| Measure | Description | Time Frame |
|---|---|---|
| Serum Total Cholesterol | Change from baseline at 2 months | |
| Serum HDL-C | Change frome baseline at 2 months | |
| Serum LDL-C | Change frome baseline at 2 months | |
| Serum TG | Change frome baseline at 2 months | |
| Serum Fasting Blood Sugar(FBS) | Change frome baseline at 2 months | |
| Serum Insulin | Change frome baseline at 2 months | |
| Serum hsCRP | Change frome baseline at 2 months | |
| Serum Insulin Like Growth Factor-1(IGF-1) | Change frome baseline at 2 months | |
| Serum IGF binding protein 3(IGFBP-3) | Change frome baseline at 2 months |
| Measure | Description | Time Frame |
|---|---|---|
| Gene Expression of IGF-1 | Change frome baseline at 2 months | |
| Gene expression of IGFBP3 | change from baseline at 2 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tehran University of Medical Sciences | Tehran | Iran |
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D004281 | Docosahexaenoic Acids |
| D015525 | Fatty Acids, Omega-3 |
| ID | Term |
|---|---|
| D004042 | Dietary Fats, Unsaturated |
| D004041 | Dietary Fats |
| D005223 | Fats |
| D008055 | Lipids |
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| Placebo | Dietary Supplement | 4 cap 1 g Placebo(paraffin) per day for 2 months |
|
| D005231 |
| Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
| D005395 | Fish Oils |
| D009821 | Oils |