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The aim of this study is to determine the effects of omega 3 supplementation and its concurrent supplementation with vitamin E on the serum levels of antioxidant enzymes and the expressions of the PGC-1a, h TERT, FOXO1, FOXO3a , SIRT1,SIRT3, SIRT6 genes in PBMC cells in the patients with coronary artery disease
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CAD, OMEGA 3 | Active Comparator | patients with CAD who receive 4 gr/day omega 3 in the form of 4 softgels each of them contains 1000 mg omega 3 and a softgel contains placebo of vitamin E |
|
| CAD, omega 3 and vitamin E | Active Comparator | patients with CAD who receive 4 gr/day omega 3 in the form of 4 softgels each of them contains 1000 mg omega 3 and a softgel contains 400 IU vitamin E |
|
| CAD, placebo | Placebo Comparator | patients with CAD who receive 4 softgels/day each of them contains placebo of omega 3 and a softgel/day contains placebo of vitamin E |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| omega 3 | Dietary Supplement |
| ||
| vitamin E |
| Measure | Description | Time Frame |
|---|---|---|
| serum total cholesterol | change from baseline at 2 months | |
| serum HDL cholesterol | change from baseline at 2 months | |
| serum triglycerides level | change from baseline at 2 months | |
| serum LDL cholesterol | change from baseline at 2 months | |
| serum insulin | change from baseline at 2 months | |
| serum Hs-CRP | change from baseline at 2 months | |
| serum gluthatione peroxidase | change from baseline at 2 months | |
| serum catalase | change from baseline at 2 months | |
| serum superoxide dismutase | change from baseline at 2 months | |
| serum total antioxidant capacity | change from baseline at 2 months |
| Measure | Description | Time Frame |
|---|---|---|
| gene expression of SIRT1 | change from baseline at 2 months | |
| gene expression of SIRT3 | change from baseline at 2 months | |
| gene expression of SIRT6 |
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Inclusion Criteria:
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literate, willingness to participation, CAD patients 45- 65 years old, body mass index< 30, avoidance of dietary supplements, vitamins and herbal products at least 3 months before and throughout the intervention, willing to maintain body weight during the study
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tehran University of Medical Sciences | Tehran | Iran |
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| Dietary Supplement |
|
| placebo of omega 3 | Dietary Supplement |
|
| placebo of vitamin E | Dietary Supplement |
|
| change from baseline at 2 months |
| gene expression of PGC-1a | change from baseline at 2 months |
| gene expression of FOXO3a | change from baseline at 2 months |
| gene expression of FOXO1 | change from baseline at 2 months |
| gene expression of h TERT | change from baseline at 2 months |
| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
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| ID | Term |
|---|---|
| D004281 | Docosahexaenoic Acids |
| D014810 | Vitamin E |
| ID | Term |
|---|---|
| D015525 | Fatty Acids, Omega-3 |
| D004042 | Dietary Fats, Unsaturated |
| D004041 | Dietary Fats |
| D005223 | Fats |
| D008055 | Lipids |
| D005231 | Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
| D005395 | Fish Oils |
| D009821 | Oils |
| D001578 | Benzopyrans |
| D011714 | Pyrans |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
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