Comparison of the Effect of Total Intravenous Anesthesia and Inhalation Anesthesia on Cancer Cell Cytotoxicity, Micrometastasis and Recurrence of Tumor in Patients Undergoing Breast Tumor Resection

The purpose of this study is to compare the effect of total intravenous anesthesia and inhalation anesthesia on cancer cell cytotoxicity, micrometastasis and recurrence of tumor in patients undergoing breast tumor resection. Using propofol-remifentanil in total intravenous anesthesia group and sevoflurane -remifentanil in inhalation anesthesia group.

Inclusion Criteria:

• patient between 20 and 65 of age with ASA physical status Ⅰ-Ⅲ
• breast cancer patients with no sign of local invasion (adjacent organs) and distant metastasis revealed by imaging studies
• surgery performed by the same surgical team

Exclusion Criteria:

• ASA physical status Ⅳ
• hepatic and renal impairment
• diabetes or other endocrine disorders
• body mass index > 35 kg/m2
• immune disorders or immunosuppressive therapy
• steroid treatment in the last 6 months
• inflammation