Anesthesia and Cancer Study: Renal Cell Carcinoma

The Influence of Type of Anesthesia on Recurrence of Renal Cell Carcinoma After Nephrectomy: a Prospective Randomized Controlled Study

This study investigates the influence of type of anesthesia on recurrence and survival of renal cell carcinoma in patients undergoing nephrectomy. The participants will be allocated to either the group receiving the total intravenous anesthesia (TIVA) using propofol or the group receiving the inhaled anesthetics, such as sevoflurane or desflurane.

The effect of anesthesia on cancer recurrence and survival is controversial. According to some retrospective studies and preclinical studies, TIVA is suggested to be more favorable than inhalation anesthesia regarding cancer recurrence and survival after surgery. However, to our knowledge, there is no study which investigates the influence of type of anesthesia on recurrence of renal cell carcinoma after nephrectomy.

Inclusion Criteria:

• Adult patients scheduled for elective nephrectomy due to renal cell carcinoma

Exclusion Criteria:

• Emergency surgery
• Pregnancy
• Allergies to anesthetics
• Palliative surgery
• Refusal to participate in the study
• History of diagnosis or surgery for other cancer