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Anesthetics agents has variety inflammation during the cancer surgery. This perioperative inflammation can influence to cancer metastasis or recurrence.
The purpose of this study is to prove the variation of immune cell activity between preoperative and postoperative period.
The patients were allocated randomly to receive propofol or sevoflurane. Also, a total of 18ml of blood sample was obtained for total 3 times in consecutive order.
Serum in blood will be obtained and activity of helper T cell, natural killer cell and level of serum cytokine will be evaluated by flow cytometry or enzyme-linked immunosorbent assay
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| propofol group | Active Comparator | The patient who anesthetized by using propofol. |
|
| sevoflurane group | Active Comparator | The patient who anesthetized by using propofol |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| propofol group | Drug | Patient will be anesthetized by using propofol infusion during operation. |
|
| Measure | Description | Time Frame |
|---|---|---|
| CD39 and CD73 on circulating regualtory T cells | change of percentage of CD39 and CD73 (scores range from 0 to 100) | preoperative time. postoperative 1 hours and 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Circulating natural killer cells | change of percentage of circulating natural killer cell (scores range from 0 to 100) | preoperative time. postoperative 1 hours and 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Circulating type 1 and type 17 helper T cells | change of percentage of helper T cell (scores range from 0 to 100) | preoperative time. postoperative 1 hours and 24 hours |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Seong-Hyop Kim, M.D,Ph.D | Konkuk University Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Konkuk University Medical Center | Seoul | 143-729 | South Korea |
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| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
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| ID | Term |
|---|---|
| D015742 | Propofol |
| D000077149 | Sevoflurane |
| ID | Term |
|---|---|
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
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| sevoflurane group | Drug | Patient will be anesthetized by using sevoflurane inhalation during operation. |
|
|
| D017437 |
| Skin and Connective Tissue Diseases |
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |
| D008738 | Methyl Ethers |
| D004987 | Ethers |
| D006845 | Hydrocarbons, Fluorinated |
| D006846 | Hydrocarbons, Halogenated |