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The major goal of this proposal is to characterize the ability of epicatechin which a component of dark chocolate to improve the
We propose that a 3 month treatment with epicatechin (through CocoaVia® capsules) will lead to a significant improvement in exercise capacity and diastolic function.
Patient Inclusion/Exclusion Criteria:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CocoaVia capsules | Experimental | From baseline to 3 months, patients will consume 2 capsules containing pure epicatechin |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CocoaVia | Dietary Supplement | CocoaVia contains flavanols found natrually in cocoa beans. Capsules will contain 250mg of flavanol |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in exercise capacity | Objectively evaluate exercise capacity through cycle ergometry to measure VO2 max | Baseline and 3 months |
| Change from baseline in skeletal muscle metabolism | The change in skeletal muscle metabolism will be evaluated by magnetic resonance spectroscopy | Baseline and 3 months |
| Change from baseline in pre-specified biomarker levels in blood, skeletal muscle, and urine | Skeletal muscle biopsies and blood draws will be performed to obtain experimental samples | Baseline and 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of California, San Diego | La Jolla | California | 92093 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22376256 | Background | Taub PR, Ramirez-Sanchez I, Ciaraldi TP, Perkins G, Murphy AN, Naviaux R, Hogan M, Maisel AS, Henry RR, Ceballos G, Villarreal F. Alterations in skeletal muscle indicators of mitochondrial structure and biogenesis in patients with type 2 diabetes and heart failure: effects of epicatechin rich cocoa. Clin Transl Sci. 2012 Feb;5(1):43-7. doi: 10.1111/j.1752-8062.2011.00357.x. Epub 2011 Nov 7. |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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