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While there is a consensus to perform pulmonary vein isolation (PVI) as a cornerstone for paroxysmal and persistent atrial fibrillation (AF), different additional ablation approaches are used for substrate modification: linear lesions, ablation of complex fractionated atrial electrograms (CFAE) or a combination of both. The aim of this study is to determine whether there is a difference in terms of freedom from arrhythmia recurrence between PVI with CFAE ablation in combination or not with linear lesions in patients with persistent AF.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CFAE ablation | Active Comparator | Intervention: Complex fractionated atrial electrograms (CFAE) Ablation |
|
| CFAE + Lines | Active Comparator | CFAE Ablation followed by linear lesions (anterior and Roof line) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PVI+CFAE+DCC | Procedure | pulmonary vein Isolation (PVI), CFAE for substrate modification and direct current cardioversion (DCC) if AF persists |
|
| Measure | Description | Time Frame |
|---|---|---|
| Freedom from atrial arrhythmia | Documented freedom from atrial arrhythmia (AF or AT) recurrence | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Procedural and safety data | Duration of procedure, ablation time, fluoroscopy time and complications | 12 months |
| Number and result of reablation procedure | Number of redo procedures, results and type of recurrent arrhythmia |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Deutsches Herzzentrum München | Munich | 80636 | Germany |
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| PVI, CFAE, anterior and roof line, DCC | Procedure | PVI, CFAE ablation. If AF persists linear lesions (anterior and roof line), cardioversion if AF persists |
|
| 12 months |
| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| D012008 | Recurrence |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D020969 | Disease Attributes |
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