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| Name | Class |
|---|---|
| Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust | OTHER_GOV |
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The optimal strategy for catheter ablation of persistent atrial fibrillation is not clearly defined. This study investigates if Complex Fractionated Atrial Electrogram (CFAE) ablation in addition to pulmonary vein isolation and linear ablations improves single procedural success rate over a 12 month follow up period.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PVI + Linear ablation | Active Comparator | Arm A: patients have PVI and roof and mitral isthmus lines |
|
| PVI + linear ablation + CFAE | Active Comparator | Arm B: patients have PVI + roof and mitral isthmus lines and CFAE ablation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Radiofrequency catheter Ablation | Procedure | In this arm, catheter ablation would be performed in the left atrium and would include pulmonary vein isolation and linear ablations (roof and mitral isthmus lines) |
| Measure | Description | Time Frame |
|---|---|---|
| Single procedural success rate (free from AF off anti-arrhythmic drugs) | 12 MONTHS |
| Measure | Description | Time Frame |
|---|---|---|
| Multiple procedure success rate | 12 months after last ablation | |
| Complication rate | 30 days of procedure | |
| Percentage of AF termination |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Royal Bournemouth Hospital | Bournemouth | United Kingdom | ||||
| John Radcliffe Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26283145 | Derived | Wong KC, Paisey JR, Sopher M, Balasubramaniam R, Jones M, Qureshi N, Hayes CR, Ginks MR, Rajappan K, Bashir Y, Betts TR. No Benefit of Complex Fractionated Atrial Electrogram Ablation in Addition to Circumferential Pulmonary Vein Ablation and Linear Ablation: Benefit of Complex Ablation Study. Circ Arrhythm Electrophysiol. 2015 Dec;8(6):1316-24. doi: 10.1161/CIRCEP.114.002504. Epub 2015 Aug 17. |
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| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| D017115 | Catheter Ablation |
| ID | Term |
|---|---|
| D000078703 | Radiofrequency Ablation |
| D000078702 | Radiofrequency Therapy |
| D013812 | Therapeutics |
| D055011 | Ablation Techniques |
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| Radiofrequency catheter ablation | Procedure | In this arm, catheter ablation would be performed in the left atrium, including pulmonary vein isolation, linear ablations (roof and mitral isthmus lines) and Complex Fractionated Atrial Electrograms (CFAE) ablation. |
|
This information will be recorded immediately after the procedure. |
| Time 0 |
| recurrence of atrial fibrillation or organised atrial tachycardia | 12 months after the last procedure |
| Ablation time | This information will be recorded immediately after the procedure. | Time 0 |
| Procedure time | This information will be recorded immediately after the procedure | Time 0 |
| Oxford |
| OX3 9DU |
| United Kingdom |
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D013514 |
| Surgical Procedures, Operative |